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真实故事改编
生日女孩
- 妳好 - 你好 - Hi there. - Hi.
真高兴见到你 So glad to see you.
卡西，麻烦一下，好吗？ Kathy, could you take that?
谢谢 Thank you.
帮必治妥药厂卖药是我的职责 而且我告诉你 It's my job to market this drug for Bristol-Myers, and I'm telling you,
除非味道像口香糖 否则小孩不肯吃 kids won't go for it unless it tastes like bubble gum.
- 克劳利先生，你要迟到了 - 好，谢谢，拜 - Mr. Crowley, you're late. - All right. Thank you. Bye.
时尚遥控汽车 1962年雪佛兰跑车
== 良医妙药 == == srt字幕转制: 样子 == == 仅供学习使用 沈阳朗思顿英语 == == Extraordinary Measures == == Srt Subtitles by William == == For Study Only - Shenyang Langston English ==
"大家都直接走过去 "Everyone just walked by.
"海绵宝宝纳闷地大叫 为什么大家都不买我们的报纸？ "'Why won't anyone buy our newspaper?" SpongeBob wondered aloud.
"派大星说 他们一定不喜欢摇滚乐" "'They must be rock haters,' said Patrick."
- 约翰！把她还给我！ - 她现在是我的了！ - John! Give it back to me! - She's mine now!
- 等我一下，好吗？ - 还给我，约翰！ - Give me a minute, okay? - Give it back to me, John!
记住我们念到哪了，好吗？ You save our spot. Got it?
你最好把我的费欧娜还我！ You better give me back my Fiona!
妈，救命！ Help, Mom!
- 救我！她要杀我！ - 我要毙了你！ - Help me! She's trying to kill me! - I'm gonna get you!
- 你逃不了的！ - 不！妈，救我！ - You can't escape! - No! Mom, help me!
把她还给我 Just give it back to me.
- 妈！她要杀我！ - 梅根凯瑟琳克劳利 - Mom! She's trying to kill me! - Megan Kathryn Crowley.
如果妳杀了妳哥哥 就别想开派对了 If you kill your brother, you cannot have your party.
为什么？他偷了费欧娜 Why not? He stole Fiona.
我没偷她，我绑架她 我要拿她来索取赎金 I didn't steal her, I kidnapped her. I'm holding her for ransom.
放了肉票 Release the victim.
准备开派对了 Time to get ready for your party.
我们必须赶快让产品上市 We've got to get moving on the product launch.
约翰，我在等法务部回复 I'm just waiting on legal, John.
该死！ Damn it!
我刚错过电车了 我再打给你… I just missed my train. I'm gonna have to call you...
好的，你何时需要？ I agree. How soon do you need it?
愈快愈好 我下礼拜要跟老板报告 As soon as possible. I'm presenting to my boss next week.
约翰，上车了，快点！ John, we're loading up the van right now. Come on!
- 准备上车了，凯特？ - 我叫珍 - Okay, we ready to roll, Kate? - My name is Jane.
- 妈，凯特是昨天的看护 - 我很抱歉 - Kate was yesterday, Mom. - I am so sorry.
中介公司太常换看护给我们 The way the agency shuffles day nurses on us,
他们应该用编号取代名字的 you'd think they'd, you know, give you a number instead of a name.
好了，约翰 Okay, John.
约翰，快点，上车了 John, come on, get your butt in the car.
约翰 John.
- 你要带滑板吗？ - 对 - Are you bringing your RipStik? - Yes.
- 非带不可吗？ - 对 - Do you have to? - Yes.
…真麻烦 等等，我得拦出租车 ...a pain, that's why. Wait, I gotta catch a cab.
嗨，出租车，嘿、嘿，拜托？ Hi. Come here. Hey, hey. Hello?
- 爸会在那里和我们会合吧？ - 当然 - Daddy's meeting us there, right? - Absolutely.
我相信他会准时到的 I am sure he has everything under control.
出租车！ Taxi!
需要帮忙吗？ You need a hand?
好极了，抱歉、抱歉，我赶时间 Great. I'm sorry, I'm sorry. I'm kind of in a hurry.
开始了 Go.
加油、加油、加油… Come on, come on, come on, come on, come on, come on.
太好了！ Yes!
好耶！
他答应会准时到的 He totally promised he'd be here by now.
他在路上了，宝贝，他在路上了 He's on his way, baby. He's on his way.
嗨，各位 Hi, guys.
- 快过去亲她 - 我知道 - Get in there and give her a kiss. - I know.
- 我不听、我不听 - 快去、快去 - I don't wanna hear it. I don't wanna hear it. - Go, go, go.
生日快乐，我来了 Happy birthday. I made it.
- 耶！ - 耶！ - Yay! - Yay!
许愿吧，梅根 Make a wish, Megan.
谁要吃蛋糕？ Who wants cake?
- 我要！ - 我要！ - I do! - I do!
排成一排，否则没蛋糕 Line up single file, or no cake for you.
- 好了，有几位小朋友？ - 我先！我第一！ - All right, how many do we have? - I'm first! Me first!
- 不行，我比较大 - 排到最后面去 - No, I'm the big guy. - Back to the end of the line.
费欧娜要去哪里？ So, where is Fiona going, anyway?
棒棒糖乐园吗？ Lollipop Land?
爸，我八岁了，不是小宝宝了 I'm eight, Daddy. I'm not a baby anymore.
她要开车去南极看企鹅 She's driving to Antarctica to see the penguins.
真的吗？那很远耶 Really? That's pretty far away.
她为什么不去波特兰动物园？ Why doesn't she just go to the Portland Zoo?
那里也有很多企鹅 They have a lot of penguins there, too.
- 你没听说过冒险吗？ - 是哦 - Haven't you ever heard of adventure? - Yeah.
她这一去要好几年 It's gonna take her years.
她不带行李吗？ Won't she need a suitcase?
这是冒险，冒险不需要带行李 It's an adventure. You don't need a suitcase on an adventure.
我不知道妳怎么想 如果我要去冒险 Well, I don't know about you, but if I was going on an adventure,
我会带行李 I would take a suitcase.
- 那是因为你是商人 - 没错，我是 - That's 'cause you're a businessman. - That's right. I am.
而妳八岁了，生日快乐，我爱妳 And you're eight years old. And happy birthday. And I love you.
我也爱你，爸 Love you, too, Daddy.
- 晚安，明早见 - 晚安 - Good night. See you in the morning. - Good night.
晚安 Nighty-night.
祝妳有个美梦 Sweet dreams.
晚安，爸 Good night, Dad.
- 晚安，爸 - 晚安，小家伙 - Good night, Daddy. - Night, buddy.
庞贝氏症
研究消息
庞贝氏症是一种肌肉萎缩症
患者寿命最长九年
庞贝氏症患者肌肉无力
庞贝氏症治疗理论 罗勃特史东希尔博士着
史东希尔教授 酶研究先驱
庞贝氏症主要医学研究员
罗勃特史东希尔博士 内布拉斯加州林肯
内布拉斯加州大学-(402)555-0125
没回电 下班再试
- 喂？ - 喂，史东希尔博士吗？ - Hello? - Hello, Dr. Stonehill?
- 你在听吗？喂？ - 是的 - Are you there? Hello? - Yeah.
我是约翰克劳利 不知道你有没有收到我的留言 This is John Crowley. I don't know if you've gotten any of my messages.
- 谁？ - 约翰… - Who? - John...
我的天 Jesus.
我很想和你谈谈 我从很多研究员那里得知… I'm interested in speaking with you. I understand from many researchers...
…方便的话，我想和你谈谈 ...having a conversation with you if that's convenient.
现在方便吗？ Is this a good time to talk?
史东希尔博士？喂？ Dr. Stonehill? Hello?
- 混蛋 - "混蛋？" - Asshole. - "Asshole?"
夜班护士刚刚走了 The night nurse just left.
现在几点了 What time is it?
我想你 I missed you.
真可怜，我还是很紧张 This is pathetic. I'm still dressed.
我可以帮你放松 I could help you with that.
凯特，你好 Oh my... Kate! Hi! You're early.
- 你来早了 - 已经6点了 6:00.
- 这位是… - 我叫约翰克劳利 - Have you met... - I'm John Crowley.
约翰是我丈夫 John is my husband.
那就好 Glad to hear it.
对，今天要加强她的呼吸治疗 Yeah, let's up her breathing treatments today.
- 怎么了？ - 只是感冒，就严重塞住了 - What's going on? - Just a cold. She's awfully congested.
- 以防万一，打给医生了吗？ - 我留过话了 - Call the doc just to be on the safe side? - Yeah, I left word.
甜心？我要去上班了，好吗？ Sweetie? I'm gonna go to work, okay?
要好好的哦 Feel better.
拜拜 Bye-bye.
我们已经成功地把药推销给医师了 We're already doing great marketing the drug to physicians.
若要直接推销给病人 就得用更强的策略 It's our direct marketing to patients we need to beef up.
克劳利先生，抱歉打扰了 Mr. Crowley, I'm really sorry.
艾琳在在线，她有要事找你 Aileen's on the line, she really needs to speak to you.
好，谢谢，我接一下电话…嘿 Okay, thank you. I'm just gonna... Hey.
我们在医院，医生要梅根住院观察 We're at the hospital. The doc wants Megan under observation.
- 她还好吗？ - 记得将手机带在身上 - Is she all right? - Just keep your cell with you.
- 好，我能做什么吗？ - 一旦有消息，我会再打给你 - Okay. Can I do something? - I'll call you when I know more.
我得去看梅根了 一有消息，我就会打给你，好吗？ I should really get back to Megan, so I'll call you as soon as I know anything, okay?
拜，爱妳 Bye. Love you.
- 请问一下 - 先生？ - Excuse me, please. - Sir?
我女儿梅根克劳利 刚进来住院观察 My daughter, Megan Crowley, was brought in for observation.
是的，其实他们正把她移到加护病房 Yeah. Actually, they're moving her to the ICU.
- 在哪里？ - 在那边 - Where? - That way.
- 艾琳 - 约翰 - Aileen. - John.
她有没有告诉你 费欧娜将要开遥控车去旅行？ Has she told you about the trip that Fiona's taking with her remote-controlled car?
有，她说了 甜心，妳说得对 Yeah, yes, she did. You're right. That's right, sweetie.
妳想看所有的企鹅，不是吗？ You're gonna see all the penguins, aren't you?
她会寄明信片给妳 She might send some postcards or something like that.
- 沿路有很多有趣的东西… - 没事的 - Lots of good stuff to see along the way... - It's okay.
…比如说冰山、北极熊 ...like icebergs and maybe a polar bear.
海豹如何？ How about some seals?
如你所知，庞贝氏症患者 身体各部分肌肉会逐渐无力 As you know, Pompe patients suffer muscle deterioration in every part of the body,
因此呼吸道并发症 是这疾病不可避免的症状 so this sort of respiratory complication, well, that's just an inevitable fact of the disease.
克劳利先生、克劳利太太 Mr. Crowley, Mrs. Crowley,
梅根的治疗效果不佳 Megan is not responding well.
我们能做的都做了，但她… Okay? Now, we've done everything we can, but she's just...
很抱歉，我们无能为力 There's nothing more we can do. I'm sorry.
如你所知，她已经超越 一般庞贝氏症病童的平均寿命 As you know, she was already well past the life expectancy, for, you know, Pompe kids.
毕竟，不光是肺的问题 After all, it's not just her lungs, okay?
她的心脏、肝脏等器官都受到影响 Her heart, her liver, these organs have been compromised
造成致命性地扩大 and would've become fatally enlarged.
我真希望庞贝氏症有药医 可惜就是没有 Now, I wish that we had a drug to treat Pompe, but we simply don't.
我真的很抱歉 I'm so very sorry.
听着，或许… Look, maybe...
或许知道梅根的痛苦快结束了 你们会比较欣慰点 Maybe you can find some small comfort in knowing that Megan's suffering will be over.
或许这也是种福气 Maybe you can see this as a blessing.
- 梅根？ - 救命！ - Megan? - Help!
- 救命！救命！ - 梅根？ - Help! Help! - Megan?
救命！救命！ Help! Help!
宝贝，妳听得到吗？ Baby girl, can you hear me?
- 拜托，快来人帮帮忙！ - 321室！ - Please, someone come help! - 321!
- 梅根克劳利，321室！ - 紧急急救！ - Megan Crowley, room 321, please! - Code Blue!
- 宝贝，妈妈在这里 - 快！呼叫海德医生 - Baby girl, Mama's here, all right? - Let's go! Page Dr. Heder.
- 心跳停止！ - 这边 - Asystole! - Yeah, right through here.
听得到吗？听得到妈妈吗？ Can you hear my voice? Can you hear Mama?
- 开始施压 - 我来换气管 - Starting compressions. - I'll switch her out.
- 在这边，快点 - 撑着点，梅根 - Over here, please. Quickly. - Hang in there, Megan.
- 撑着点，宝贝 - 我得让她离开 - Hang in there, baby, okay? - I need to bag her.
- 艾琳？ - 请让一让 - Aileen? - Some room right there.
让我们处理，好吗？ Let us in, all right?
- 拜托，克劳利太太… - 住手！ - Please, Mrs. Crowley, let... - Stop it!
让我们救她！ Let us help her!
- 拜托…梅根！ - 艾琳？ - Please... Megan! - Aileen.
- 肾上腺素，体重每公斤0.1毫克 - 知道了 - Epinephrine, 0.1 mils per kig. - Got it.
还是没心跳，没数据 Still no pulse. No reading.
- 别算体重了，快拿来！ - 艾琳、艾琳 - Forget the weight, come on, get it in there! - Aileen, Aileen.
- 0.1毫克 - 好 - 0.1 epi. - It's all right.
- 加油，梅根，加油 - 增加点滴量 - Come on, Megs. Come on. Come on. - IV push.
- 每隔几秒给一次肾上腺素 - 还是没反应 - Okay, just give the epi a couple seconds. - Still non-responsive.
- 准备电击 - 电击 - All right, charge the defib. - Charging.
你女儿是个斗士 Your daughter is some fighter.
- 她会没事的 - 我的天 - She's gonna be okay. - Oh, my God.
听好，她还是很虚弱 Now, look, she's still a very sick girl, obviously,
但她的生命迹象进步了 我很审慎乐观 but her vital signs have improved and I'm cautiously optimistic.
你意思是 我们躲掉了那个福气，是吗？ So, I guess you could say we dodged that blessing, huh?
- 克劳利太太，这些是给梅根的 - 谢谢、谢谢 - Mrs. Crowley, these came for Megan. - Thanks so much. Thank you.
嘿，约翰？ Hey, John?
等你准备好就开始 Any time you're ready, man.
你要跟大家说明产品上市计划？ You gonna tell us about the product launch?
约翰，你还好吗？ John, you okay?
我得走了 I have to go.
约翰 John.
- 你要去哪？ - 内布拉斯加州 - Where you going? - Nebraska.
内布拉斯加州大学-林肯市 生化学院
打扰一下，有位先生要见你 Excuse me, please. There's a gentleman here to see you.
最好坐下来等吧 Best make yourself comfortable, hon.
哦，天啊 Oh, dear.
先生、先生 刚离开的就是史东希尔博士，抱歉 Sir, sir. That's Dr. Stonehill. He just left, I'm sorry.
- 谢谢 - 不客气 - Thank you. - Yeah.
史东希尔博士！ Dr. Stonehill!
嘿，史东希尔博士！ Hey, Dr. Stonehill!
史东希尔博士？ Dr. Stonehill?
- 什么事？ - 我是约翰克劳利 - Yeah? - I'm John Crowley.
- 好的 - 你有没有收到我的留言？ - Okay. - Didn't you get any of my messages?
什么留言？ What messages?
最近一个月 我留了三、四通留言给你 I left you three or four messages in the last month,
最后一通留言的前一晚 你还挂了我电话 and you even hung up on me the night before last.
你在说什么？我从没挂你电话 What the hell are you talking about? I never hung up on you.
史东希尔博士 我有两个孩子得了庞贝氏症 Dr. Stonehill, two of my kids have Pompe.
哦，我的天 Oh, Jesus.
我很遗憾 Well, I'm sorry.
这种病很严重 A terrible disease,
但你不该大老远跑来找我 but, hell, you shouldn't have come all this way without talking to me.
我做研究，不看病人 I do research, son. I don't see patients.
我有兴趣的就是你的研究 Well, it's your research that I'm interested in.
我看过所有关于庞贝氏症的报导 I've read all the journal articles on Pompe disease,
而且所有医学研究员都说 你的理论最有可能成功 and all the researchers out there say that your work holds the most promise.
说重点吧，你要我做什么？ Get to the point, son. What do you want from me?
我上周差点失去了我的女儿 We almost lost my daughter last week.
我必须听听你的研究 I need to hear about your research.
你的孩子有基因缺陷 Your kids have a genetic disease.
他们缺少一种酶 They're missing an enzyme
无法转化肝糖 which metabolizes a certain kind of sugar, glycogen.
这是庞贝氏症患者的缺陷 It's defective in Pompe patients.
这种糖大量储积在肌肉细胞内 So, this sugar builds up in the muscle cells,
尤其是心肌、骨骼肌、横隔膜 especially in the heart, the skeletal muscles, the diaphragm,
导致呼吸困难 which is why they have a hard time breathing.
- 是的，那些我都知道 - 大家都在生产酶 - Yeah, I know. I know a lot about that. - Everybody's making an enzyme,
你可以整天帮孩子打酶 but you can infuse kids all day long with their enzyme,
但那是没用的 因为酶不会进入细胞中 and it's not gonna do any good 'cause it's not gonna get into their cells.
懂吗？ Understand what I'm saying?
懂，意思是如果把糖… Yeah, so that means that if you put the sugar...
- 别打岔 - 抱歉 - Don't interrupt. - Sorry.
我在制造不同版本的酶 I'm making a different version of this enzyme.
我的酶有生物标记 甘露糖6-磷酸盐 My enzyme has a biological marker, mannose 6-phosphate.
只有我能复制基因里的磷酸转移酶 I'm the only one that's cloned the gene for phosphotransferase.
只有我能复制基因里的催化酶 I'm the only one who's cloned the gene for uncovering enzyme,
所以我可以让更多甘露糖6-磷酸盐 进入溶酶体蛋白 so I can get more mannose 6-phosphate onto the lysosomal protein,
并把大量的有效酶 and I can deliver a more effective amount of enzyme
送进细胞中 into the cells.
所以大家才会引用我的研究 That's why people are citing my work.
你也才会从文献中看到我的名字 That's why you read my name in the literature.
我可以把更多酶送进细胞中 I can get more enzyme into the cells.
怎么了，莎尔？ 妳没听说过糖生物学吗？ What's the matter, Sal? Not up on your glycobiology?
我以为博士只是你的绰号 I thought Doc was just your nickname.
不，这个人是个天才 他将有重大医学突破 No, that man's a genius. He's on the verge of a scientific breakthrough.
哇，还真看不出来 Wow. Who knew?
我没有什么突破 这只是个理论，不是疗法 I'm not on the verge of anything, kid. This is a theory, not a therapy.
我只是个学者 I'm just an academic.
- 知道我有多少研究经费吗？ - 不知道 - You got any idea how shitty my funding is? - No.
内布拉斯加州大学 付给足球教练的年薪 University of Nebraska pays their football coach
比我整个医学研究预算还多
没人在乎这种研究 Nobody's paying attention to this work.
我的一半补助金都没被批准 Half my grants don't get approved.
我没有经费将理论制造成实际药物 I don't have the money to make my theory into a useable medicine.
你的孩子几岁了？ How old are your kids?
六岁和八岁 Six and eight.
听好，帮你自己一个忙 回家好好陪孩子 Look, do yourself a favor. Go home and spend time with your kids.
趁他们还在时，好好陪他们 Enjoy 'em while they're still here.
- 多少？ - 什么东西多少？ - How much? - How much what?
要多少钱才能证明你的理论 How much money would it take to prove your theory,
并制造成实际药物？ to create your version of the medicine?
我需要五十万元资助实验室 I'd need half a million bucks just to fund the lab work.
- 所以你需要我 - 我需要你？为什么？ - That's why you need me. - I need you? Why?
因为我是儿童庞贝氏症基金会的创办人 Because I'm the founder of the Pompe Foundation for Children.
我研究这个病十年了 I've been working on this disease for 10 years.
从没听说过这个基金会 I have never heard of you guys.
那是因为我们相当新，还在筹备阶段 That's because we're relatively new. We're just in the gearing-up phase.
- 你何时需要钱？ - 现在有最好 - How soon do you need a grant? - Now would be good.
钱还没全募完，不过很快就会有了 Well, not all the money's in place, but it will be, and soon.
真是令人兴奋的时刻 This is a very exciting time.
- 谢了 - 谢了，先生，祝愉快 - Thanks. - Thank you, sir. Have a good day.
机场快捷服务
嘿 Hey.
妳还好吗？ You okay?
- 有收到我的留言吗？ - 你的留言？ - Did you get my messages? - Your messages?
你开会开到一半突然跑掉 You suddenly walk out of the meeting
而且没跟我说 就直飞内布拉斯加州 and fly to Nebraska without talking to me about it,
你想留言有用吗？ and you think messages make it okay?
- 抱歉 - 我的天，约翰 - I'm sorry. - My God, John.
我跟你一样想寻找奇迹，好吗？ I wanna find a miracle as much as you do, okay?
但你怎么能拿工作开玩笑？ But how could you put your job in jeopardy?
- 艾琳 - 如果 - Aileen. - How exactly
保险没了 每个月四万元的医疗费要怎么付？ do we pay $40,000 a month in healthcare if you lose your insurance?
我不会失去工作的 Honey, come on. Look, I'm not gonna lose my job.
真的吗？ Oh, really?
皮特昨晚打了两次电话来 问你的状况 Pete called here twice last night to ask if you were okay.
精神状况 You know, mentally.
我会… 我会回电，也会摆平这件事的 I'll just... I'll call, and I'll smooth that one over.
最好如此 Yeah, no shit.
我很抱歉 I'm sorry.
我突然领悟到 Something in me just kind of snapped.
那晚在医院里 当我们以为快失去她时 That night at the hospital, when we thought that we were losing her,
我祈祷如果她时候到了 I prayed that if it was her time,
就赶快走，不要忍受那么多苦 she'd go quickly, without so much suffering.
但隔天早上，她撑过来了 But morning came, and she pulled through.
她的眼神 Her eyes,
如此坚决、勇敢 so determined, so defiant.
充满奋斗力 The fight in her.
这位叫史东希尔的家伙 值得吗？ Was he worth it? This Stonehill guy?
他很古怪 但他的理论比其它人先进 He's really eccentric, but his science is way ahead of everybody else's.
- 绝对值得我们投资 - 只要我们有钱的话 - He's definitely the one to put our money on. - Lf we had any.
我答应他，我们会募款 I promised him that we'd raise some,
因为下个月他会来这里开会 because he's got this conference up here next month,
我说过我会准备支票给他 and I said I'd have a check ready for him.
- 多少？ - 五十 - How much? - Five hundred.
- 就这样？ - 万 - That's all? - Thousand.
是五十还是一万？ Is it $500 or $1,000?
是五十万 $500,000.
下个月 By next month.
- 亲爱的，你疯了吗？ - 显然是的 - Sweetheart, are you totally insane? - Apparently.
我们会在本月23日 于学校举办第一次募款活动 We're holding our first fundraiser on the 23rd at the school,
希望你和法兰克能参加 and we would love if you and Frank could join us.
- 准备好拼字测验了吗？ - 好了 - Ready for your spelling test? - I'm gonna nail it.
祝好运 Okay. Good luck.
我是奥勒岗州的约翰克劳利 My name's John Crowley. I'm calling from Oregon,
我从亚特兰大区 家有庞贝氏症儿协会得知您的 and I got your name from the Atlanta-area Pompe parents' group.
是的 Yeah.
很抱歉在同学会时没见到你 And I was so sorry not to see you at the reunion
因为你是我高中时期最要好的朋友 because you were one of my most favorite people in high school.
总之，约翰和我在筹备这个基金会 Anyway, John and I are starting this foundation.
- 嘿，爸？爸 - 不，你懂我的意思 - Hey, Dad? Dad. - No, you know what I mean.
只是想改变情况 Just make it right.
- 爸？ - 你没看到我在讲电话吗？ - Dad? - Can't you see I'm on the phone?
- 好，告诉我他怎么说的 - 爸！ - Okay, well, tell me what he told you. - Dad!
不，我再回你电话 我不说了，好，拜 No, I'm gonna have to call you back. I can't talk. All right, bye.
- 什么事？ - 我把滑板卖了 - Yeah, what is it? - I sold my RipStik.
好的 Okay.
这些够不够 梅根和派屈克的基金会使用？ Is it enough to give to Megan and Patrick's foundation?
够，比什么都还够 Yeah, it's more than enough.
- 你是约翰吗？ - 是的 - Are you John? - Yes.
- 马可斯坦伯，我们通过电话 - 对，幸会 - Marcus Temple. We spoke on the phone. - Right. Absolutely. Good to see you.
- 大老远从亚特兰大来 - 是的 - All the way in from Atlanta. - Yes.
这是我从亲朋好友及教会那里 募来要给基金会的 Well, this is for your foundation, from my relatives, friends and church group.
我的天 My goodness.
谢谢你 Thank you very much.
谢了 Thanks.
- 嗨，史东希尔博士，我是梅根 - 嗨，梅根，我是史东希尔博士 - Hi, Dr. Stonehill. I'm Megan. - Hi, Megan. I'm Dr. Stonehill.
是啊，所以我才说 "嗨，史东希尔博士" Yeah, that's why I said, "Hi, Dr. Stonehill."
- 你到底要不要进来？ - 要，谢谢 - Are you coming in or not? - Yeah, thanks.
妈妈和爸爸呢？ Where's Mom and Dad?
他们马上下来 They'll be down in a minute.
派屈克的呼吸警报器坏掉了 他们在修理 Patrick's vent alarm is going off, so they need to fix it.
他的警报器比我的更常坏掉 His alarm goes off even more than mine.
你呢？你结婚了吗？ So, what's your deal? You married?
你有老婆吗？ Do you have a wife?
有两位前妻 Ex-wives. Two of 'em.
- 是吗？怎么会？ - 因为我太随和了 - Yeah? How come? - 'Cause I'm so easy to get along with.
- 还有其它问题吗？ - 没有，换你问我了 - Any other questions? - No. Your turn to ask one.
你大概在猜我几年级 You're probably wondering what grade I'm in.
- 妳几年级？ - 我三年级 - What grade are you in? - I'm in third.
我的兴趣是打电动和看企鹅，你呢？ My hobbies are video games and penguins. How about you?
- 我已经毕业了 - 不，我是说兴趣 - I already graduated. - No, I mean hobbies.
我大部分都在工作 Mostly I just work.
久久会去钓一下鲈鱼，但是… Little bass fishing every once in a while, but...
妳最喜欢什么科目？ What's your favorite subject?
我喜欢阅读，但我最喜欢体育课 尤其是短跑 I'm good at reading, but I like P.E. Best, especially the sprint races.
短跑？ Sprint races?
- 想见识一下吗？ - 当然 - Wanna see? - Sure.
来吧 Come on.
- 他来了吗？ - 我不知道 - Is he here yet? - I don't know.
我快赢了！ I'm gonna win!
快点，慢郎中 Come on, slowpoke.
好耶，我赢了！ Yeah, I won!
我赢了 I won.
好耶 Oh, yeah.
我就说我会打败你 Told you I'm gonna beat you.
嗨 Hi.
史东希尔博士有两位前妻 Dr. Stonehill has two ex-wives.
- 我想梅根已经自我介绍了 - 是的 - I see that Megan's introduced herself. - Yeah.
- 你好吗，史东希尔博士？ - 很好，谢谢 - How are you, Dr. Stonehill? - I'm okay, thank you.
- 这是我太太，艾琳 - 幸会 - This is Aileen, my wife. - So nice to meet you.
- 还有小约翰 - 哈啰 - And John Jr. - Hello.
- 他是派屈克 - 嗨 - Here's Patrick. - Hi.
- 嘿，派屈克 - 我想我们该回屋里了 - Hey, Patrick. - I think we should probably go inside.
是啊，进来吧 Yeah, come on inside.
梅根，屋里头见，快点 Megan, we'll see you inside. Come on.
- 晚安，派屈克 - 晚安 - Night, Patrick. - Good night.
晚安，海绵宝宝 Night, SpongeBob.
- 你得跟史东希尔博士道晚安 - 亲一下海绵宝宝 - You gotta say good night to Dr. Stonehill. - Kiss SpongeBob.
- 晚安 - 晚安，小家伙 - Good night. - Good night, son.
晚安，派屈克 Good night, Patrick.
我不想再说一次，该睡觉了 I'm not gonna say it again. It is bedtime now.
这是要送他的 It's for him.
- 我吗？ - 祝你钓到鱼 - Me? - For good luck. For bass fishing.
谢谢 Thank you.
喜欢吗？ You like it?
当然，一个小福星 很有个性，对吧？ Well, sure. A happy-go-lucky little fellow, lots of personality, huh?
- 他是个塑料玩具 - 我知道 - He's a plastic toy. - I know.
这是父女之舞 Here's the father-daughter dance.
等你看过梅根跳轮椅舞后 你才能完全体会 You haven't lived until you've seen Megan do the Wheelchair Watusi.
给你 Here you go.
- 趁水果派热的时候吃吧 - 好香，亲爱的 - Go ahead and eat the cobbler while it's hot. - Smells great, honey.
真是好笑 This was hilarious.
巴伯，我们去了这家观光农场 我可以叫你巴伯吗？ Bob, we went to this dude ranch. All right if I call you Bob?
给我五十万元支票 就算叫我佩姬也行 You got a check for a half-million dollars, hell, you can call me Peggy Sue.
我只是… I'll just...
巴伯 Well, Bob.
这是五十万元的头期款 This is the first installment against the promised half a million.
91250元 约翰克劳利
老实说这比我预期的还多 Tell you the truth, that's more than I expected.
史东希尔博士，我们保证… Dr. Stonehill, we promise that...
- 我懂 - 如果…时间够的话… - Yeah, I know. - Lf... In enough time, then...
我懂、我懂 I know. I know.
从现代的网络中 你可以获知一个人的背景 You can learn a lot about a person on the Internet these days.
一个从新泽西州来的工人小孩 Learn about a working-class kid from New Jersey,
靠打工念完哈佛商学院 worked his way through Harvard Business School,
在必治妥药厂，努力往上爬 clawing his way up the ladder at Bristol-Myers.
但网络不会告诉你 But what Google can't tell you
这个害怕、绝望、又爱吹牛的混蛋… is that this scared, desperate, bullshitting son of a bitch...
- 请等一下… - 别打岔 - Wait just a minute... - Don't interrupt.
会不计一切代价，取得成果 Will do and say whatever it takes to get results.
所以你和我要一起开公司，泽西小子 Which is why you and me are going into business together, Jersey.
你说什么？ Excuse me?
我受够了跟大学讨经费 I'm tired of begging breadcrumbs from the university
以及把我的智慧财产让给他们 and giving them the patents to my ideas.
他们不重视我的研究，但你重视 They don't value my work. You do,
所以我要成立自己的公司 which is why I'm setting up my own shop.
我需要一位 Figure any dude in a business suit
帮我筹措资金及经营公司的经理人 can help me raise venture capital and run the company,
但谁会比想救自己孩子的父亲 更积极呢？ but who's gonna be half as motivated as a dad who's trying to save his own kids?
所以这是… So, this is...
这是你遇过最差的工作 So this is the shittiest offer you're ever gonna get.
我可以跟你保证 钱少、工作时间长、环境差 I can promise you less money, longer hours, lousy working conditions,
另外，等钱筹到后 你就得到内布拉斯加上班 plus, if we raise the money, you're gonna have to relocate to Nebraska.
在适当的经营计划下 And with the right business plan,
我也可以跟你保证 会有治疗庞贝氏症的有效酶 I can also promise you a working enzyme for Pompe disease.
你知道的，我不能治愈你的孩子 他们必须坐轮椅 I can't cure your kids, you know that. They're always gonna be in wheelchairs,
但我想我能救他们的命 but I think I can save their lives.
水果派很好吃 Outstanding cobbler.
好、好，我们同意不让孩子搬家 Okay, okay. So, we agree we can't uproot the kids.
要是史东希尔失败了呢？ What if Stonehill fails?
或是他成功得太晚 来不及救梅根和派屈克呢？ Or what if he succeeds too late to help Megs and Patrick?
- 然后呢？ - 我知道 - Then what? - I know.
如果很快就会失去他们 你会希望每分每秒陪在他们身旁 If we're gonna lose them young, you want to spend every minute you can with them.
约翰，你飞到内布拉斯加州的那天 John, that day that you flew to Nebraska,
当你突然抛下工作… when you suddenly just ditched work and...
我的天，我以为你发疯了 你吓到我了 My God, I thought you'd lost it. You scared me.
但是当我们卷起袖子 But once we rolled our sleeves up,
开始募款及见到其它庞贝氏症家庭时 and we started fundraising and meeting other Pompe families,
让我觉得… it made me feel like...
我们该接受命运 I mean, do we just accept our fate
并照那些好心医生所说的 and do what we're told by all the well-meaning doctors
等待那天的到来 还是我们该向命运挑战？ and wait for the worst to happen, or do we fight it?
我想你做错决定了，真的 I think you're making a mistake. I really do.
就算你的信用像总裁一样好 而你并没有 Even if you were credible as a CEO, which you are not,
你的成功机率还是很渺茫 九成的生技公司都倒了 the odds against you are crushing. Nine out of 10 biotechs crash and burn.
当你破产、没工作、没医疗保险时 So where does that leave your kids when their dad is flat broke
你的孩子怎么办？ with no job and no health insurance?
若留在必治妥 Now, if you stay at Bristol,
高层主管准备在第三季升你当副总 the guys upstairs are ready to put you in the VP slot at the end of the third quarter
另外再加四成薪 with a 40% salary bump.
约翰 John.
你家人需要那笔钱，不是吗？ Your family's gonna need that money, aren't they?
皮特，你说得对，这很疯狂 Pete, you're right. This is crazy.
我在做不可能的任务 I'm chasing the wind.
但我不能 But I can't just
眼睁睁地看着我的孩子迈向死亡 sit around and wait for my kids to die.
我做不到 I can't do it.
内布拉斯加州
你已经到达目的地 You have arrived at your destination.
请进，门没锁 Come on in. It's open.
- 嘿，巴伯 - 嘿，约翰 - Hey, there, Bob. - Hey, John.
你好吗？ How are you?
- 这里不难找吧？ - 不难 - You have trouble finding me? - No problem.
- 坐吧 - 谢了 - Sit down. - Thanks.
前妻，她爱猫 Ex-wife. She loved cats.
所以我们… Well, say, what do we...
我们要做什么？ 我们为下周和瑞兹勒开会 What are we gonna do? How about we work up a strategy
拟一套策略，如何？ for the meeting at Renzler next week?
我们不必给这些家伙看什么 We don't need to show those guys anything.
开会只是个拘泥形式 The meeting's a formality.
乔治瑞兹勒和我 在医学院时就认识了 George Renzler and I have known each other since med school.
他跟我说了好几年 如果我采取大动作 He's been telling me for years that he'd give me the seed money
成立自己的公司 他就会提供我资金 if I ever decide to make the big move and set up my own shop.
很好、很好，但还是一样 Well, that's good. That's good, but, still, all the same, you know,
要推销，就必须有具体东西 if we're gonna go in to pitch 'em, we should have something tangible.
那些家伙了解我，他们是真正的医学家 Those guys understand me. They're real scientists.
不像那些搞生技的大金主 They're not like a lot of these big biotech moneymen.
好吧，那么我们就讨论一下重点 Okay. All right, tell you what, how about if we just talk it through,
然后建立基本经营计划吧？ and then that way we can just sketch up something rough on paper?
你告诉我医学研究 我来拟定经营计划 You give it to me, I'll make up a business plan.
我们必须拟一套真实策略 那些家伙是创投家 We need to rough out a real strategy. These guys are venture capitalists.
那些够你拟了吗？ That rough enough for you?
巴伯？瑞兹勒是关键 没有他们，我们就得不到 Bob? Look, Renzler's crucial to us. Without them onboard, we got zero credibility
- 其它金主的信任 - 所以才需要你啊！ - with any of our investors. - That's why you're here, Jersey!
明天前准备好那个屁计划 Whip up some business bullshit by tomorrow.
- 我要去钓鱼 - 这…这些毫无意义！ - I'm going fishing. - This is... This is gibberish!
那么你最好赶快工作 Then you better get busy.
回头见 See you.
芝加哥
瑞兹勒 创业投资公司
如你所知，罕见疾病药物的 潜在市场是很大的 As you know, the market potential for an orphan drug is enormous.
如果你还在商学院，我会给你优等 If you were still in business school, I'd give you an A
因为这些图表做得很棒… for all these lovely charts and graphs and...
但你已经毕业了 But school is out.
在座多数人都是医学家 我们必须看到医学理论 Most of us here are scientists. We need to see the science.
巴伯，说服我们吧 Bob, make us believe.
乐意至极，乔治 Love to, George.
…磷酸转移酶及第二催化酶… ...the phosphotransferase and the second uncovering enzyme...
此刻的挑战是扩大生产线 At this point, the challenge is to scale up this process
制造更多的HPGAA to produce kilogram quantities of HPGAA.
然而问题是合不合乎成本效益 And the question is whether or not it's cost-effective
是该委外生产 还是该建立自己的生产线 to contract this work out or to build our own manufacturing facility.
不管怎样，我们最终还是需要 大约一千万的资金 Either way, we're gonna eventually need an investment on the order of $10 million.
在这么短的时间内 说了这么多 It's a lot of information in a short period of time.
有没有人有问题？ Does anybody have any questions?
- 太了不起了 - 谢了，乔治 - This is astonishing. - Well, thank you, George.
这家伙在这行里领先群雄 This man is light years ahead of the field.
好 Okay.
不如让你的财务人员和约翰一起讨论 Well, why don't you have your money guys get together with John
- 合作细节… - 听来不错 - and work out the business... - Sounds great.
当然，我们需要你说明一下 实际的东西 Of course, we'll need you to explain some of the mundane stuff, Bob,
也就是基本细节 the nuts and bolts.
- 基本细节？什么… - 是的 - Nuts and bolts? What... - Yeah.
你是个优秀的学者 You're a brilliant theoretician,
但你没有新药上市的经验，对吧？ but you've never actually brought a new drug to market before, right?
对，我没有新药上市的经验 No, I've never brought a drug to market. I haven't.
我意思是，举例来说 你要如何取得磷酸转移酶？ I mean, for example, how are you getting the phosphotransferase?
我会从乳牛的乳腺里纯化出来 I'm purifying it out of a lactating bovine udder.
你要从哪里取得乳腺？ I see. And where are you getting the udders?
牧场啊 From the stockyards.
- 简单得很 - 不见得 - Pretty straightforward stuff. - Not really.
- 你不能把乳牛蛋白注入人体 - 我知道 - You can't inject cow protein into people. - I know that.
乳牛酶是实验用的 做为观念的证明 The bovine version of the enzyme is for lab work, for proof of concept.
我会复制人类酶做真正的药物实验 I'll make a copy of the human enzyme for actual drug trials.
- 催化酶呢？ - 怎样？ - What about uncovering enzyme? - What about it?
你要如何做出 How exactly do you plan on making
- 完整复制品？ - 我用T293 - an exact replica? - I'm making it in T-293,
胎儿肾脏细胞制造 out of human kidney cells.
- 我的天，不行 - "我的天，不行？" - Oh, my goodness. No. - "Oh, my goodness. No?"
不行，药管局不会批准 No. The FDA will never allow that.
- 嘿，巴伯… - 等一下 - Hey, Bob, just... - Wait a second.
看在上帝分上 我们会在临床实验前，改变细胞株 For Christ's sake, we will change the cell line before clinical trials.
你应该要在很早以前 就规画好那些过程… You've gotta have that process locked down long, long before you think about...
巴伯，喝杯咖啡，休息一下… Bob, why don't we just take a coffee break...
你跟我说这干嘛？ 我不要喝该死的咖啡 Why are you talking to me this way? I don't want any goddamn coffee.
巴伯，你能不能告诉我们 Bob, can you just tell us how you're planning to make
在药管局批准及GMP认证下 你计划如何制造这三种酶… the three enzymes under FDA-approved GMP in...
我不是来说明次要细节的，乔治 I'm not here to cross every "t" and dot every "i", George.
我也不是来被当做医学院新生 被评估及质询的 And I'm not here to be poked and prodded like a first-year med student.
- 这太可笑了 - 巴伯 - This is ridiculous. - Bob.
荒谬至极 This is bullshit.
巴伯 Bob.
巴伯，如果答不出来，你就说会再研究 Bob, if you can't answer a question, you say you're working out the details.
你不能像个被宠坏的孩子 负气离开，好吗？ You don't storm out on these guys like some sort of spoiled child, okay?
- 现在，我们得回到里头 - 不，我不回去 - Now, we're gonna go back in there. - No, I'm not going back in there.
我们要回到里头 巴伯，这是公事、不是私事 We're going back in there. This is business, Bob. It's not personal.
刚刚那是私事 That was personal.
史东希尔中途离席，毁了那场会议 Stonehill goes and completely sabotages the meeting.
谢谢 Thank you.
我是说，才刚起步，就被他彻底毁了 I mean, he completely blew my plan, right out of the gate.
好吧，他是个不定时炸弹 但你还相信他的理论吗？ Okay, I get that he's a loose cannon, but do you still believe in his science?
亲爱的，如果我筹不到一千万 Honey, if I don't raise $10 million in capital,
他的理论就不重要了 his science doesn't matter. At all.
他的手臂怎么了？ What's going on with his arm?
嘿，小家伙，你还好吗？ Hey, buddy, you okay?
- 你还好吗？ - 我再也不能丢东西了 - You all right? - I can't throw them anymore.
- 怎么会这样？ - 我不知道 - When did this happen? - I don't know.
- 你该帮帮他，爸 - 好主意 - You should help him, Daddy. - That's a good idea.
好，我们来丢吧，预备 Okay, here we go. You ready?
- 一、二… - 丢到水里 - One, two... - Into the water.
丢得好，我们可以丢得更好 That was a good shot. We can do better than that.
再试一次，我们把它当做弹丸 Try again. Let's make, like, a little pellet.
来吧，小鸭鸭 Here, ducky, ducky.
再来一次 Let's do it again.
预备？一、二、三 Ready? One, two, three.
再给我一片，约翰 Give me another piece, John.
我直接丢啰 I can just throw them.
你负责笑、我负责丢 And you do all the laughing, and I'll do all the throwing.
很好，鸭子吃到了 That's good, the ducky shared.
- 看到没？ - 看到了 - Did you see that? - Yeah.
约翰？ John?
- 我们没时间了 - 我知道 - We're out of time. - I know.
他没力气丢面包屑给鸭子吃 He doesn't have the strength to throw a piece of bread to a duck.
- 简直吓死我了 - 我也是 - It scares the hell out of me. - Me, too.
约翰，你在做什么？ John, what are you doing?
我要提供瑞兹勒一个 他抗拒不了的交易 I'm offering Renzler a deal he can't turn down.
芝加哥
不好意思，早安，瑞兹勒博士？ Excuse me. Morning. Dr. Renzler?
瑞兹勒博士？ Dr. Renzler?
先生，早安 Sir, good morning.
- 克劳利 - 是吗？ - John Crowley. - Crowley?
- 是 - 你来干嘛？ - Yes, sir. - What are you doing here?
- 早 - 早 - Good morning. - Good morning.
我从你秘书那里得知 你要到法国 I understand from your secretary that you're going to be leaving for France
- 一个月 - 是的 - for a month. - That's right.
我有个提案要给你 I have a proposal for you, and I was hopeful
- 希望你能看一下 - 我们在赶飞机 - that you could take a look at it. - We're running late for a flight.
我明白，只要几秒钟，请你看一下 I appreciate that. It'll only take a second, just to have a quick read.
- 好吧，我会在车里看 - 你会有兴趣的 - Fine. I'll read it in the car. - It might interest you.
好，谢谢 Good, thank you.
- 史东希尔知道这件事吗？ - 当然 - Does Stonehill know about this? - Of course.
他也同意这些条件啰？ And he's okay with these terms?
你只要签名就行了 All I need is your signature.
林肯市-内布拉斯加州大学 生物化学学院-欧斯默厅
哈啰？ Hello?
巴伯 Bob.
巴伯
巴伯！ Bob!
在这里 Over here.
巴伯 Bob.
巴伯！ Bob!
嗨，巴伯 Hi. Bob.
你怎么了？ What'd you do to yourself?
- 我拿到瑞兹勒的资金了 - 什么？ - I got the investment from Renzler. - You what?
听着，我要你在看这份合约前 Listen, I want you to
好好思考一下 think about something before you read that.
这是什么？ What the hell is this?
在这情况下 这是我们能拿到最好的交易了 Under the circumstances, this is the best deal that we could ever get.
这不是交易，这是投降条约… This isn't a deal. This is the terms of our surrender, for...
瑞兹勒拿了几百万元来 Renzler comes in for a couple of million now,
你就让他当合伙人？ and you give him the option of jumping in as a full partner later?
在你毁了会议后 我不得不做得戏剧化点 Well, after sabotaging our meeting, I had to do something dramatic.
你还跟他保证 一年内会做临床实验？ And you promise him we'll be in clinical trials in a year?
巴伯，我们做得到的，好吗？ We can do this, Bob. All right?
我们努力点，逼自己跟时间赛跑 We work harder, we push ourselves, we work around the clock.
我已经在跟时间赛跑了！ I already work around the clock!
你干脆把我的鸟蛋装在罐子里 送给他们好了 Why don't you just give 'em my balls in a jelly jar?
我没有别的方法 让他们回到会议桌上 There's no other way I could get them to come back to the table.
谁需要这些畜牲！ Who needs the bastards anyway!
瑞兹勒不投资 其它创投公司根本也不会投资 Without Renzler, there's no reason for us to even think about other venture groups.
很好！那就别投资！ Fine! Then I won't think about other venture groups!
很好！ Great!
用你后半辈子的时间 梦想那得不到赞助的伟大点子 Spend the rest of your life dreaming up great ideas that don't get funded.
尽情在墙上画 理论上能治病的精采图表 Draw brilliant diagrams on the wall that cure diseases in theory,
但在现实中永远也帮不了任何人 but never help a single human being in reality.
你还好吗？让我看看 What'd you do? Let me see it.
- 它只是… - 让我看看 - It's just barely... - Let me see.
把它按住 Put pressure on it.
这玩意全是你的血 Got your blood all over this thing.
要我滴一滴血，让它变成正式文件吗？ Want me to add a drop of mine, make it official?
还是签名就好？ Or would a signature suffice?
巴伯？ Bob?
内布拉斯加州 两个月后
超过一个单位两万两千元 我一个子都不会付，好吗？ I'm not paying a dollar more than 22,000 a unit, okay?
办不到 I'm not doing it.
嗨，巴伯 Hi, Bob.
这些家伙让我觉得变老了 These guys make me feel old.
老医学家会比较谨慎敏感 Scientists get all sensible and careful when they get old.
年轻医学家喜欢冒险 Young ones like risk,
不怕新点子 not afraid of new ideas,
而且可以少付点钱 and you can pay 'em less.
我们都相信巴伯史东希尔的大胆理论 否则你们不会在这里 We all believe in Bob Stonehill's bold vision, otherwise you wouldn't be here.
但要在一年内进行临床实验 But to reach clinical trials inside of a year,
我必须要求各位 全力执行最艰难的工作进度表 I'm gonna have to ask you to commit to a brutal schedule.
各位先生女士 请把手表重新调到派兹梅时间 Ladies and gentlemen, reset your watches to Priozyme Time.
派兹梅时间！
- 要多久？ - 三、四小时 - How long? - Three, four hours.
要是能再快点就好了 Well, if you can get it any quicker, that'd be good.
我会努力 I'll try.
不准在我的冰箱冰该死的食物！
拜托 Come on.
- 去检查断路器 - 好的 - Vinh, check the breakers. - Got it.
- 整栋楼都停电了 - 启动备用发电机 - No, the whole building's out. - Well, get the backup generator going.
- 我们… - 等等 - We... - Wait, wait, wait.
你根本没买备用发电机？ You never bothered to buy a backup generator?
这里常有龙卷风 We're in the middle of tornado country,
- 我的天！ - 我是气象学家吗？ - for Christ's sake! - Yeah, so I'm a meteorologist?
冰箱要是停电超过45分钟 整个细胞株就完了 If I don't have my refrigeration back in 45 minutes, I lose the whole cell line.
四个月的辛苦白费了！ Four months of work pissed away!
这不在预算内，我们没钱买 It was never in the budget. We never had the money for it.
- 抱歉，先生，你的卡被退了 - 什么？ - I'm sorry, sir. Your card, it's been denied. - What?
我帮实验室买了滚瓶反应器，卡刷爆了 It got maxed out. I bought the roller bottle unit for the lab.
该死，我… Shit, I...
月底要还我，不然我会被房东赶出来 Just pay me back by the end of the month, or I lose my apartment.
嗨，给妳，谢了 Hi, here you go. Thanks.
太好了！ Yes!
太好了！
先生 Sir.
谢谢 Thank you.
费欧娜这周在墨西哥 那里有金字塔 Fiona's in Mexico this week. They've got pyramids there.
她去南极前还有很多东西要看 She's still got lots of things to see before she gets to Antarctica.
是哦 Yeah.
她要用斧头砍死所有的企鹅 She's gonna chop up all the penguins with an ax.
把血淋淋的尸体拿去喂海象 And feed their bloody remains to the walruses.
是哦 I see.
什么？ What?
你每次周末回家 都不听我说话 Every time you come home for the weekend, you don't even listen to me.
小梅 Megs.
妳说得对，我很抱歉 You know what, you're right. I'm sorry.
只是我一直很忙 It's just that I've been so busy
努力为妳和派屈克制造特效药 trying to make the special medicine for you and Patrick.
- 我要粉红色的 - 妳要什么？ - I want it pink. - You want what?
特效药，我要粉红色的 The special medicine. I want it to be pink.
好，我想我能要求史东希尔博士 Okay. I guess I can ask Dr. Stonehill.
告诉他要像这种暗粉红色 不是小宝宝的淡粉红色 Tell him dark pink, like this. Not light pink. That's for babies.
好的 Okay.
请吧 Here you go.
瑞兹勒博士，请讲讲理 公司才开六个月 Dr. Renzler, be reasonable. The company is only six months old,
我们进展得很快，即将进行动物实验 and we are making great progress towards in vivo testing.
我不知道，公司花钱的方式… I don't know. The way the company is burning money...
我们必须取得竞争优势 Well, we've got to get a leg up on the competition.
你知道吉玛根公司 财力比我们雄厚 You know that Zymagen has far more spending power than we do.
所以你意思是 我应该要投资吉玛根 So, what you're saying, I should have invested in Zymagen.
不，我意思是 我们必须抢在他们之前成功 No, what I'm saying is, is that we've got to beat 'em to the punch.
不然的话，吓吓他们 让他们并购我们 Either that, or scare them into buying us out.
你没吓到吉玛根 反而吓走一堆投资者 Well, you're scaring us investors a hell of a lot more than you're scaring Zymagen.
想办法把公司卖给吉玛根 You sell the company to Zymagen,
并在会计年度结束前进行临床实验 you're in clinical trials by the end of the fiscal year,
不然我们就撤资、停止损失，再见 or we pull the plug and cut our losses. Goodbye.
喂？ Hello?
架构看来很好 This construct's looking pretty good,
但我们必须得到 阿法和贝塔单体之间更好的细胞分裂 but we gotta get better cleavage between the alpha and the beta subunits.
如果我们像催化酶那样 加入劈开酶呢？ Well, what if we add a furin site like the one in uncovering enzyme?
为什么那么做？它不是有… Why would you wanna do that? Doesn't it have its own...
我们必须谈谈 We need to talk.
- 我很忙 - 你总是很忙 - I'm busy. - You're always busy.
你总是要谈 You always wanna talk.
对，我们可以加入劈开酶 并试着在纯化前劈开它 Yeah, we could add furin and try and cleave it before purification.
你在做什么？ What are you doing?
- 让你预习一下… - 各位，给我们一分钟好吗？ - Giving you a preview... - Guys, would you excuse us for a minute?
…如果四个月后 没进行临床实验，会怎么样 ...of what's going to happen if we are not in clinical trials in four months.
我们的金主会关掉所有的灯 Our investors will turn out the lights.
科学需要时间，泽西小子 他们不懂吗？ Science takes time, Jersey. Don't they understand?
他们懂 他们会读《华尔街日报》 Yeah, they do. They can read the Wall Street Journal.
知道吉玛根正在实验三种不同的 庞贝氏症药物 They see that Zymagen is testing three different Pompe drugs.
他们实验三种 是因为他们搞不清楚状况 They're testing three 'cause they don't know what the hell they're doing.
- 我实验一种是因为这是对的！ - 我知道，我相信你，巴伯 - I'm testing one 'cause it's the right one! - I know. I believe you, Bob.
不然我干嘛忍受你的坏脾气？ Why else do you think I put up with all your shit?
听好 Look.
我要你直接面对吉玛根的医学家 I want you to go toe-to-toe with Zymagen's scientists.
- 跟他们证明你的酶是最棒的 - 我可以做得到 - Prove to them that your enzyme is best. - I can do that.
所以我已经跟他们协议好 That's the reason I've entered into conversations with them
并购我们的公司 to buy our company.
你是在告诉我？不是问我？ You're telling me? You're not asking me?
别这样，巴伯 我只是负起财务方面的责任 Come on, Bob. I am just being fiscally responsible.
任何人都不能指使我 如何管理我的实验室！ Nobody is gonna tell me how to run my lab!
如果我能促成这件事 还真的是"如果" If I can engineer a deal, and that is a really big "if,"
你会因为我帮你弄到的钱 而原谅我的 you're going to have to forgive me for all the money I'm gonna make you.
我才不在乎钱 I don't care about money.
我是医学家，我在乎的事比钱更重要 I'm a scientist. I care about more important things than that.
别跟我说什么更重要 Don't you tell me about more important things to care about.
自己算算看吧 Do the math.
不是卖了公司，拿到大笔资金 Either we sell the company and get a huge cash infusion,
就是让金主把公司给关了 or the investors will shut us down.
你要去哪？ Where you going?
如果财务上许可的话 我要去撇个条 I'm gonna go take a crap, if that meets with your fiscal approval.
他们难道不能像平常人 从机场开车过来吗？ What, they can't drive from the airport like ordinary people?
巴伯，我们务必要成功 Bob, we need to make this happen.
他们会问艰难的问题 They're gonna ask us some tough questions.
别把它当做私人攻击，好吗？好吗？ Don't take 'em personally, all right? All right?
实验结果证实了 我多年来提倡的理论 These lab results confirm what I've been preaching for years,
也就是磷酸转移酶 是酶吸收作用的关键 that phosphorylation is key to enzyme absorption.
我的理论能治疗庞贝氏症 My theory works for Pompe,
最后也能适用在 其它溶酶体酶储积症的 and eventually it'll work for enzyme replacement therapies
酶替代疗法 for other lysosomal storage disorders.
- 会不会太复杂？ - 太复杂？ - Is it too complicated? - Too complicated?
你的方法所含的变量之多令人咋舌 The number of variables built into your approach are mind-boggling.
我是说，天啊 只要你在合成中弄错一个元素 I mean, Jesus, if you get even one piece wrong in the synthesis,
只要一个糖错位… just one carbohydrate ends up in the wrong position...
那么就得做对 值得做的事就要做对 Well, it's gotta be done right, like anything worth doing.
你从没真正开发过药物 You've never actually gotten a drug approved.
你是不是天真地以为 自己能解决这类的生产问题？ Isn't it naive to think you can solve these kinds of manufacturing challenges?
巴伯？巴伯？ Bob? Bob?
你说得对，我是个理论派的家伙 You're right, I'm a theory guy.
我的想法不够实际 My head is in the clouds.
所以我们才需要你们 Which is why we need you.
除非你们解决 Unless, of course, your reputation
蛋白质生产问题的美誉 只是空穴来风 for solving protein-manufacturing problems is undeserved.
说得好 Nice one.
- 我还是想听听利润率 - 当然、当然 - I still need to hear about profitability. - Certainly, certainly.
如你们所知 这不是一次疗程，这是终身疗程 As you know, this is not a one-time treatment. It's a lifelong therapy.
然而这些病人 And these patients,
他们必须终身用药 因此会带来长期收入… they are going to generate revenue over the span of their lifetime that is...
但就算你制造出有效的酶 也不是所有病患都适用 But even if you make a usable enzyme, clearly it won't work for all patients.
因此多少的存活率 才能达到相当的利润？ So, what survival rate do we need to achieve a robust profit?
多少的死亡率 才能被视为可接受的损失？ What rate of patient death can be defined as acceptable loss?
可接受的损失？ Acceptable loss?
我了解你的问题 I understand the question.
因为孤儿药品的利润相当高… Because the profit margins on this orphan drug are so incredibly high, the...
就算五年后死亡率是百分之二十五 Even with a mortality rate of, say, 25% over five years still indicates
收入仍然相当可观 that there is a highly lucrative revenue source to be realized.
各位，我们成交了 Gentlemen, we have a deal.
西雅图
吉玛根
罗勃特史东希尔博士 要见贝里瑞尼 Dr. Robert Stonehill to see Barry Renee.
罗勃特史东希尔博士 要见瑞尼博士 I have a Dr. Robert Stonehill to see Dr. Renee.
- 先生，你必须换证 - 我只是要上洗手间 - Sir, you need to be cleared. - I'm just gonna use the restroom.
- 你必须换证才能上洗手间 - 只是要… - You need to be cleared to do that, sir. - Just need to...
- 你必须换证 - 老天 - You need a security badge. - Jesus.
可以给我尿尿的通行证吗？ Well, can I have a security badge so I can go take a pee?
好，先生，他会帮你换证 Yes, sir. He will give that to you.
- 嘿，巴伯 - 嘿，约翰 - Hey, Bob. - Hey, John.
觉得自在点了吗？ You getting comfortable?
请定义"自在" Define "comfortable."
你还没兑现？ You haven't cashed it yet?
我还没赚到它 I haven't earned it yet.
等酶成功后，我才会去兑现 I'll cash it when we have a usable enzyme.
受款人罗勃特史东希尔博士 六百万元
波特兰
真的很美 Well, it sure is beautiful.
真的很大 It sure is big.
孩子们会爱死的 The kids love it.
把握每一天 Seize the day.
好的 Okay.
我得讲完这通电话 I'm stuck on this call.
约翰，我们很高兴你能加入团队 Just wanted to let you know how thrilled we are to have you onboard, John.
我的荣幸 It's an honor.
- 记得肯特韦伯博士吧 - 当然 - You remember Dr. Kent Webber. - Of course.
- 真高兴又见面 - 我也是 - It's good to see you again. - Good to see you, too.
你们俩好好配合吧 I'll let the two of you get into it.
- 我期待美好的结果 - 是的，先生 - I'm expecting great things. - Yes, sir.
我有几个好点子 能帮助这四个核心酶小组 I've got some pretty good ideas about how to help the flow of information
彼此之间的讯息交流 between the four core enzyme groups.
约翰，慢慢来 那不是我们的既定程序 Whoa, John, slow down. That's not our established procedure.
你说什么？ Pardon me?
这四个核心酶小组 基本上彼此互相竞争 The four core teams are essentially in competition with each other.
这是企业经营模式，很有效率 It's an entrepreneurial model. It works.
我完全赞成竞争 但一定要有一些管道 I'm all for competition, but surely there must be some channel
分享医学资源 进而帮助这四种酶的开发 for allowing sharing scientific insights that can help develop all four enzymes.
约翰，为了节省我们的时间 请恕我直言 John, in the interest of saving us time, let me be blunt.
这里多数医学家都不认同 Most of the scientists here don't like the idea
让一位非医学家担任 庞贝氏症计划案的资深副总 of having a non-scientist as senior VP of the Pompe program.
尤其是他的小孩 Especially one whose objectivity
还罹患此病 因此可能会缺乏客观性 might be clouded by having children with the disease.
为了你好，我必须告诉你 I'm telling you this in your own best interests.
艾瑞克想买史东希尔的点子 Erich wanted to buy Stonehill's ideas,
但没连你也买下来的话 他就买不到 and he couldn't do that without also swallowing you as part of the pill.
约翰，我建议你最好保持低调点 My advice to you, John, is to keep your head down.
- 谢谢你的忠告 - 不客气 - Thank you for that wisdom. - You're very welcome.
你实验室里所有的手册 必须交给审查委员会！ All of your lab notebooks must be submitted to the review committee!
你实验室里所有的手册 必须交给审查委员会！
这是我的实验室！滚出去！ This is my lab now! Get out!
我只是在说明程序！ I'm just trying to explain the protocol!
- 你在浪费我的时间 - 史东希尔博士… - You're wasting my time. - Dr. Stonehill...
算了 Fine.
你要做什么？ What do you want?
我只是过来说 我想我们可能失去了一个 I just dropped by to say that I think that we might be missing an opportunity
能和其它三个核心小组沟通的机会 to open a dialogue with the other three core teams.
其它核心小组？核心小组 The other core teams? Core teams.
核心个屁 Core bullshit.
我下次再来 I'll come back another time.
肌肉逐渐无力是很棘手 The decline in muscle strength is very troubling, of course,
但这两个孩子 but it's really, in both kids,
器官扩大的情况 肝脏、尤其是心脏 the organ enlargement, the liver, and especially the heart,
才是真正威胁着他们的生命 that's the real threat to their lives.
我们会继续监视 心脏扩大的速度 We'll continue to monitor the rate of cardiac enlargement.
- 也会继续观察其它器官… - 多久？ - We'll keep tabs on their other organs... - How long?
- 我不想预测 - 求求妳 - I don't like to predict. - Please.
卫德曼医生，我们不会怪妳的 我们只是必须知道一些事 Dr. Waldman, we won't hold you to it. We just need to know something.
约翰 John.
我们还有多久的时间？多久？ How much more time do we have? How long?
这个嘛 Well,
如果又发生呼吸困难，一切就甭谈了 if there's another respiratory crisis, all bets are off,
不然的话 but otherwise,
梅根也许一年 Megan, maybe a year.
派屈克，少于一年 Patrick, less.
谢谢妳 Thank you.
马可斯 Marcus.
- 电话 - 怎样？ - Get the phone. - What?
- 电话 - 是谁？ - The phone. - Who is it?
- 喂？ - 嗨，你是马可斯吗？ - Hello? - Hi. Is that Marcus?
- 是的，几点了？ - 抱歉，很晚了 - Yeah, yeah. What time is it? - Yeah, I'm sorry. It's late.
- 我是约翰克劳利 - 约翰，怎么了？ - It's John Crowley. - John, what you doin'?
你还好吗？ You okay?
听好，我想请你帮个忙 Hey, look, I gotta ask you a favor.
- 早安，盖文 - 早安 - Morning, Gavin. - Morning, sir.
十一点的会议确认了吗？ Is my 11:00 with Henessey confirmed?
确认了 还有在楼下餐厅有个早餐会 Yes, and there's the breakfast meeting down in the cafeteria.
早餐会？ Breakfast meeting?
电邮是周末传进来的 There was an e-mail that came in over the weekend.
庞贝氏症小组都被邀请了 Everyone on the Pompe project was invited.
- 谁召开的会？ - 我想是克劳利先生 - Who called the meeting? - Mr. Crowley, I believe, sir.
什么？ What?
常常有人问我 我们怎么会生两个有庞贝氏症小孩 Something that people ask me all the time is how we have two kids with Pompe.
在我们知道梅根罹患庞贝氏症时 By the time we realized that Megan had Pompe,
我已经怀了派屈克了 I was already pregnant with Patrick.
我数不清我们看过多少位医生了 I mean, I can't tell you how many doctors we saw,
结果都一样 and the message was always the same,
庞贝氏症没有药医 that there is no drug to treat Pompe.
但感谢各位，这一切将会有所不同 But thanks to you, all of you, that message is changing.
你们带给我们以及许多家庭希望 What you've given us, and a lot of other families, is hope.
谢谢各位 So, thank you.
做得好，艾琳 Good job, Aileen.
现在让我们掌声欢迎坦伯一家人 Now I'd like to welcome the Temple family,
他们大老远从乔治亚州过来 参与我们今天的盛会 who've come all the way from Georgia to be with us here today.
谢了，约翰 Thanks, John.
嗨 Hi.
我是马可斯 I'm Marcus.
她是我太太，温迪 This is my wife, Wendy.
我们的长女，萝兰 Our daughter Lauren, our oldest daughter,
今天本来想过来 亲自跟大家问好 Lauren wanted to come today and say hi to all you guys.
她很虚弱 She's a little weak,
但她要我们带她的照片给大家看 but she wanted us to show you guys her picture
并传达她对各位的爱 and to send you her love.
这是我们的女儿，梅根 And this is our daughter, Megan.
所有漂亮女孩都叫梅根 The most beautiful girls are named Megan.
梅根只有四个月大 你们还看不出来 Megan is four months old, and you can't see it yet,
但她也罹患庞贝氏症 but she has Pompe, too.
我… I...
我无法形容 这对我们来说意义有多重大 I can't tell you what it means to us
能有各位为我们的孩子开发新药 to have all of you working on a medicine for our children.
谢谢各位 Thank you.
谢谢 Thanks so much.
- 嘿，肯特 - 约翰 - Hey, Kent. - John.
你觉得这个活动如何？ So what did you think of the event?
约翰，在做医学研究时 客观是关键 In medical research, John, objectivity is key.
如果研究员太情绪化 If researchers get all emotional,
急着想帮助受苦的病患 他们就会找快捷方式 all desperate to help suffering patients, they'll cut corners.
这会产生不良后果 It's counterproductive.
不良后果就是 这四个核心小组的医学家 Counterproductive is having four core teams of scientists
全为同个疾病努力，却不互相沟通 working together on the same disease, but not talking to each other.
那些家伙多半没看过庞贝氏症病童 Most of these guys have never even seen a kid with Pompe before.
我不觉得那有什么关联 I don't see how that's relevant.
你刚看到艾瑞克了吗？ 那种冲劲就是我们要的 Did you see Erich? That's the kind of motivation that we need.
我会要求他让小组停止竞争 开始一起合作 I'm gonna ask him to get the core team to stop competing, start working together.
建立一个领导小组 Create a leadership team.
如果你想推动领导小组这想法 Well, if you hope to sell this leadership team idea,
只有一个方法能说服艾瑞克 there's only one way to convince Erich.
什么方法？ And what's that?
让你的人，史东希尔 远离这个小组 Keep your guy, Stonehill, off the team.
他才到职几天 就企图疏离所有的同事 In his short tenure here, he's managed to alienate a remarkable number of colleagues.
你不能把他放在一个 必须团结合作的小组里 You can't put him on a team that's supposed to build cooperation.
自己衡量看看 要不要建立领导小组 So, decide how badly you want your leadership team,
然后做你该做的事 then do what you have to do.
真是够了 That's it.
史东希尔博士，麻烦一下 Dr. Stonehill, please.
关小声点，对 Turn it down. Yes.
对，音乐 Yes, the music.
我说小声点！ I said down!
这家伙真难搞 This guy's impossible.
我喜欢那首歌 I like that song.
嘿 Hey.
怎么了，约翰？ What's up, John?
- 家里一切还好吗？ - 还好 - Everything all right at home? - Yeah.
你有没有听说艾瑞克罗林 Have you heard that Erich Loring
同意成立一个领导小组？ has agreed to put together a leadership team?
有，我听说了，真是狗屁不通 Yeah, I heard some rumor about it. What bullshit.
现在我每周得拨几小时 跟吉玛根的人闲扯 Now I'm gonna have to spend a couple of hours a week jawin' with Zymagen guys?
不 No.
不，你不用 因为我不会把你放进小组里 No. No, you won't, 'cause I'm not putting you on the team.
你刚说什么？ What'd you say?
我是很想 I really wanted to.
你不会把我放进小组里？ 你刚是那么说的吗？ You're not putting me on the team? Is that what you said?
你是什么？学校田径教练吗？ What are you, some varsity track coach?
他们不是因为你的风度翩翩 而买我们公司的，泽西小子 They didn't buy our company 'cause they like your Ivy League charm, Jersey.
他们是因为我而买的 It's me they wanted.
你不能驱逐我 这违反了自然法则 You can't bench me. It's against the laws of nature.
你还是可以证明你的理论是对的 You're still gonna be able to prove that your theory is right.
但其它医学家会评估我的结果，对吧？ 不是我 Yeah, but other scientists are gonna evaluate my results, right? Not me.
这里每个人都尊重你的研究 Everyone here reveres your science.
问题出在与人的互动上 This is about interpersonal issues.
- 谁叫你这么做的？ - 我自己决定的 - Who put you up to this? - The decision was mine.
这是为了整体考量 It's for the overall good of the program.
"整体考量" "For the overall good of the program."
约翰，你很会说企业用语 Wow, John, you really got the corporate lingo down good.
接下来呢？"可接受的损失"吗？ What's next, "Acceptable loss?"
不 No.
真的有人会吗？ Does anybody really know how to do this?
除了我们 Except for us.
- 等等，换谁了？ - 还是约翰 - But wait, who's going? - It's John's turn still.
任天堂运动游戏 Nice one.
丢得好
好，我来接 Okay. I'll get it.
丢得好，梅根 Nice one, Megs.
喂？马可斯，嗨 Hello? Marcus, hi.
哦，我的天 Oh, my God.
老天，差点全倒 Man. I almost got 'em down.
你们坐好，好吗？ 约翰，抱一下牠 You guys sit tight, okay? Here, John, grab him.
如果需要帮忙，任何事都行 打给我们，好吗？ If there is anything we can do, anything at all, will you call?
好，我们很爱你们 Okay. We love you guys so much.
好，拜拜 Okay, bye-bye.
艾琳 Aileen.
是马可斯坦伯 That was Marcus Temple.
萝兰… Lauren...
她… She...
他说她在睡梦中过世 走得很安详 He said she went in her sleep, that it was peaceful.
她几岁？ How old is she?
萝兰几岁？ How old was Lauren?
萝兰九岁 Lauren was nine years old.
过来 Come here.
那样我们就能确定 我们开发正确的酶 That way, we can be certain that we're developing the correct one.
别管确不确定了 让我们找出成功机会较大的酶 Forget certainty, and let's try and figure out which enzyme has the better odds.
如果我们只开发一种酶 If we develop only one enzyme,
要是选错了，会怎样？ what would happen if we guessed the wrong one?
克劳利先生 我请肯特制定了一套实验方案 Mr. Crowley, I've asked Kent to set up a testing protocol
帮我们选出对的来 to help us guess right.
我们会做全面性实验 We'll do an exhaustive range of tests.
我称它为"实验之母" I'm calling it "The Mother of All Experiments."
四种酶会用颜色编码 黄、蓝、绿和红 The four enzymes will be color-coded, yellow, blue, green and magenta,
研究员只能看到颜色代码 and known only by those color codes
因此没人知道自己测试的是哪一种 so no researcher will know which one he's testing.
等选出优胜者后，再公布秘密身分 Only after we pick a winner, the secret identity will be revealed.
来吧，梅根！ Come on, Megan!
但我想要！ But I want to!
- 手腕动一动 - 动不了 - Just roll your wrist. - I can't.
没关系，试试另一个 It's okay. It's all right. Let's try another one.
好了，再试一次，预备好没？ Okay. Let's try again. Ready?
预备？ Ready?
一、二、三，开始！ One, two, three, go!
- 大赢家！ - 好耶！ - Big winner! - Yay!
妳看看，妳得到一只企鹅 Here you go, look at that. You got a penguin.
嘿，巴伯、巴伯 Hey, Bob. Bob.
你好吗？ How you doin'?
我带了肋排给你 I brought you some ribs.
没有角落餐厅那么美味 Not as good as the ones from The Corner Saloon,
但如果你饿了的话… but if you're hungry...
你想做什么？ What do you want?
"实验之母"的 The results.
实验报告 "Mother of All Experiments."
这个嘛 Well,
他们选了哪一种酶？ which enzyme did they choose?
领导小组花了一整个下午辩论 The leadership team spent the whole afternoon arguing.
黄色和绿色酶 遥遥领先其它两种 Two enzymes, coded yellow and green, are ahead of the others,
却不分上下 but it's too close to call.
明天我们会花一整天的时间辩论 再决定优胜者 Tomorrow, we spend the day hashing it out to decide which one to choose.
巴伯，请你读读这个 Bob. I'm asking you to read this.
我把你的意见 看得比世上任何人都重要 I value your opinion more than anyone else in the world.
也许你该早点重视我的意见 Well, maybe you should have valued my opinion a little sooner,
而不是替高层扮演刽子手 instead of playing hatchet man for the bean counters.
- 滚出我的实验室 - 知道这件事对你有利，巴伯 - Get the hell out of my lab. - It's in your interest to know about this, Bob.
出去 Get out.
- 难道你不觉得… - 出去 - Wouldn't it benefit you... - Get out.
绿色酶最佳 给他们看我的分析，他们会懂的 The green enzyme's the best. Show 'em my analysis, they'll understand.
嘿，等等，巴伯 Hey, wait up, Bob.
绿色酶是你的吗？ Is the green enzyme yours?
我认得报告里的模式 我从一哩远就能认出我的宝贝 I recognize patterns in the results. I'd know my baby a mile away.
- 所以绿色是你的啰？ - 不是 - So the green one is yours? - No.
不是 No, it's not.
我的理论仍是最棒的 但它还没准备好生产 My theory is still the best, but it's not ready for manufacture.
他们的平凡粗糙，但准备好了 Theirs is crude and uninspired, but it's ready.
巴伯，我不知道该怎么谢你 Bob, I don't even know the words to say thank you.
别谢了 Don't bother.
我不是为你做的 I didn't do it for you.
太好了！ Yes, it is!
- 老天，你有没有看到风筝？ - 有 - Oh, my gosh. Do you see the kite up there? - Yeah.
好酷哦！ That's so cool!
安妮，小心！ Annie, careful!
- 盖一座堡垒 - 在那里，好 - Building a bastion. - Right there. Yeah.
- 发射！ - 好！ - Three! - Okay!
爸，像…预备？ Dad, like... Ready?
- 爸，你保证不再讲电话的 - 我知道、我知道，但是… - Dad, you promised no more phone calls. - I know. I know I did, but...
里头有什么？ What's in there?
等我回来时 我们轮流把电话埋起来 We can take turns burying the phone when I get back.
好！我来挖洞 Okay! I'll start digging a hole.
- 等一下吧 - 我是约翰克劳利 - You hold that for a sec. - John Crowley.
约翰，我是肯特韦伯 John, it's Kent Weber.
肯特，你有没有看到 我提的临床实验方案？ Kent, hey. Did you get my suggested protocol for the clinical trials?
有 Yeah.
你把我们要实验的对象 You made some pretty optimistic assumptions
估得太乐观了 about where our enzyme supply will be.
我懂 I see.
你要比较实际点的… Well, what do you think that a more realistic...
约翰，我实话实说吧 我们只做婴儿的临床实验 John, I'll give it to you straight. The clinical trial will be for infants only.
婴儿需要的酶比较少 Infants need so much less enzyme,
如你所知，最初的供应量有限 and, as you know, our initial supply will be so limited.
况且用在婴儿身上 And the drug has much higher odds of being effective
成功机率比大一点的儿童还高 with infants than with older children.
这件事我们必须和艾瑞克讨论 我们必须和艾瑞克讨论 We have to consult Erich on this. We have to consult Erich.
我已经问过了，他确认只做婴儿实验 I already did. He confirmed the decision. Infants only.
我了解你有私人考量… I understand your personal reasons for...
做决定时必须客观、理性 These decisions have to be made objectively, rationally.
我很抱歉，我… I'm sorry. I...
真的很抱歉 I really am.
西雅图
吉玛根 一级安检
酶P146 50毫克
不准动 Hold it, pal.
- 克劳利先生，你在这里做什么？ - 我只是… - Mr. Crowley, what are you doin' in here? - I was just...
- 你没被授权 - 不…，我可以解释 - You're not authorized. - No... I can explain everything.
怎么了，查克？有问题吗？ What's the matter, Chuck? Is there a problem?
是有问题 克劳利先生擅自闯进这里 Yeah, there's a problem. I got Mr. Crowley in here without clearance.
这是我的错 That's my fault, now.
我在实验室里忙不过来 叫泽西小子进来帮我拿几瓶酶 I got busy in the lab, I sent Jersey boy here to get me a couple jugs of enzyme.
抱歉 Sorry.
谢了，查克 Thanks, Chuck.
谢谢你救我 Thanks for saving my ass.
你很宽宏大量 It's really big of you,
尤其在我们之间发生不愉快后 especially after what went down between us.
你是指你冷血无情的背叛吗？ You mean your ruthless, cold-hearted betrayal?
当我以你的立场想时… Yeah, well, when I thought about it from your point of view...
该死，如果我的孩子快死了 我也会毫不犹豫地背叛你 Shit, if it was my kids dying, I wouldn't have hesitated to crush you like a bug.
记得我们初次相遇时 Do you remember when we first met,
你跟我说我该停止追求奇迹 and you told me that I should stop chasing miracles
回家去，趁孩子还在人世时 and should go home and enjoy my kids,
好好陪他们吗？ while they're still here?
- 记得 - 我做了一个错误的选择 - Yeah. - I made the wrong choice.
- 泽西小子，知道什么叫手足研究吗？ - 不知道 - Jersey, you know what a sibling study is? - No.
对遗传基因相同的两名病患 进行临床实验 It's a drug trial with just two patients with the same genetic inheritance.
罹患同疾病的亲手足 Siblings, with the same disease.
梅根和派屈克 Megs and Patrick.
吉玛根会批准这种实验吗？ Well, would Zymagen go for something like this?
这有重要的研究价值 There's real research value in it.
多两名病患，不会用掉太多酶 And with just two patients, it wouldn't take much enzyme.
但必须得到韦伯的批准 But Webber would have to sign off on it.
等我们准备就绪后，再告诉他 Well, let's not tell him till we've got our ducks in a row.
我来拟方案 看看能不能找到愿意配合的医院 I could draw up a protocol and see if I can find a hospital willing to administer it.
- 巴伯 - 先别抱太高的期望 - Bob. - Well, don't get your hopes up, kid.
我们只能孤注一掷 It's a Hail Mary.
呱！
鸭子就位了 Ducks in a row.
"史东希尔、仔细审查、提案 手足实验146 "Stonehill, careful review, protocol, Sibling Trial,146,
"在此告知您，我们接受 "are pleased to inform you Megan Crowley and Patrick
"梅根及派屈克的实验！" "have been accepted into the trial!"
- 我刚收到了 - 呱、呱、呱 - I just got it. - Quack, quack, quack.
你跟他谈了吗？ Have you talked to him yet?
没有，我负责研究、你负责推销 No. I did the science. You make the sale.
谢谢 Thank you.
- 祝好运 - 好的 - Good luck. - Right.
- 他能给我五分钟吗？ - 可以 - Does he have about five? - He does, yeah.
- 谢了 - 不客气，克劳利先生 - Thanks. - No problem, Mr. Crowley.
嘿，肯特？打扰一下 Hey, Kent? Knock-knock.
有空吗？ Got a minute?
肯特？ Kent?
- 你知不知道自己做了什么？ - 你说什么？ - Do you have any idea what you've done? - Excuse me?
我们今早接到波特兰萝丝医院的电话 We got a call this morning from Portland Rose Hospital,
要我们寄酶过去 治疗你的孩子？ about sending them enzyme for your kids?
对，我知道 我就是来和你谈这件事的 Right. Yeah, I know. That's what I'm here to talk to you about.
你和史东希尔背着我做这件事 现在却跑来找我 You and Stonehill set this up behind my back. Now you come to me.
只是暂时的 It's all tentative.
你要公司赞助一项药物研究 You want this company to sponsor a drug study,
对象是公司内部高层主管的两名小孩？ for two children whose father is an executive of this company?
你没听过"利益冲突"吗？ Have you never heard the term "conflict of interest?"
这是两回事… It has nothing to do with a...
知道药管局发现后会怎样吗？ Do you know what the FDA would do if they found out?
这项研究能提供有力的医学证明 There is strong scientific justification for this study.
也有很高的研究价值 There is great research value.
我是博士，约翰，我懂研究价值！ I'm a doctor, John. I know the research value!
但你们不能不跟我们商量 就私自进行！ But you guys just can't go off half-cocked without consulting us!
我相信如果找艾瑞克谈… And I'm sure that if we just go and talk to Erich, we can...
艾瑞克已经知道了 Erich already knows.
- 他很生气被蒙在鼓里 - 我不是要隐瞒谁 - He's furious about being blindsided. - I didn't try to blindside anyone.
这就是为什么我们有报告制度 This is the reason why we have a reporting structure,
有既定程序及提案制度 why we have established procedure, why there is protocol.
你是个无情无义的机器 You heartless, bloodless machine.
你就是要跟我做对到底！不是吗？ You just have to fight me every step of the way! Don't you?
从我把庞贝氏症病患带到公司来后 你就开始恨我了！ You just hated it when I brought the kids with Pompe to the doorstep!
你让自己的孩子加入实验计划时 也没考虑到那些病童 You weren't thinking about those kids when you put your children into that program
而且还危及到 公司费时十年的研究投资！ and jeopardized a decade's worth of research investment made by this company!
重点不在于投资报酬！ This is not about a return on an investment!
重点在于孩子 It's about kids,
这些孩子有名字、有梦想 kids with names, dreams,
也有爱他们的家人 families that love them.
你危及到了你孩子的治疗机会 You've jeopardized your chances of ever getting your kids treated.
我不和你讨论医学问题！ I'm not arguing science with you!
在每个阶段，你都站在… On every level! On every level, you've stood...
很抱歉我擅自寻找 手足实验的可行性
造成大家的困扰…
我刚在写道歉信 给资深管理部门 I was just drafting a letter of apology for senior management,
但我想似乎不必写了 but I guess we're past that point.
我刚和艾瑞克谈过了 我们要终止雇用你 I just spoke to Erich, and we are terminating your employment.
好吧，我会收拾我的东西 Okay, I'll pack up my stuff.
有一件事，约翰 Just one thing, John.
我也许是个难搞的经理人 I may well be a tight-ass pencil-pushing company man,
但我痛恨被称做无情的人 but I resent being called heartless.
- 听着… - 让我说完 - Look... - Just let me finish.
我们终止雇用你的原因是 The reason we're terminating your employment,
避免利益冲突 is to eliminate the conflict of interest.
这是我们的同事 史东希尔博士提的方案 This strategy was brought to my attention by our colleague, Dr. Stonehill,
条款相当简陋 in rather crude terms.
这样手足实验就能纯粹因为 This will allow the sibling trial to proceed
医学价值而进行 for its purely scientific value.
今天下班前把办公室清干净 Have your desk cleared out by the end of the day.
肯特，这是… Kent, what's with the...
我只想确定在我告诉你前 你不会把我打昏 I wanted to make sure you didn't punch me out before I could tell you.
这个嘛 Well,
- 谢谢你开除我 - 我的荣幸 - thank you very much for firing me. - My pleasure.
- 我从不喜欢你 - 我也一样 - I never liked you. - Likewise.
嘿，想带什么就带… Hey, you guys, bring anything you want extra...
- 妈！ - 怎样？ - Mom! Mom! - What?
- 我可以带弓箭吗？ - 可以 - Can I bring the bow and arrow? - Yes, yes.
嘿！ Hey!
约翰，怎么… John, what...
怎么了？ What?
我们的酶准备做临床实验了 We have a usable enzyme that's ready for clinical trials.
什么时候？什么时候会有？ When? When will it be ready?
梅根和派屈克这个月底前 开始注射 Megs and Patrick start their infusions before the end of this month.
- 我的天 - 是啊 - Oh, my God. - Yeah.
我的天 Oh, my God.
约翰 John.
嘿，约翰，爸回来了 Hey, John, Daddy's here.
- 嗨，各位 - 嘿，爸 - Oh, hi, guys. - Hey, Dad.
妈妈为什么难过？ Why is Mommy sad?
不是难过，宝贝，是喜极而泣 Not sad, baby, so happy.
真的很开心 So happy.
妈妈为什么这么奇怪？ Why is Mommy being so weird?
这是因为我们有特效药 Well, it's because we got the special medicine
可以治疗梅根和派屈克 你们很快就能接受治疗了 for you, Megs, and for you, Patrick, and you're gonna get it really soon.
太好了！ That's great!
波特兰萝丝医院
谁要按按钮？ So, who wants to push the button?
梅根、派屈克，准备好没？ Megs, Patrick, you ready?
什么时候会知道有没有效？ When will we know if it's working?
要一阵子，亲爱的 It'll be a while, honey.
这不是粉红色的 It's not pink.
不好意思，你们的巴比叔叔来访 Excuse me? Your Uncle Bobby is here.
我不知道 I don't know.
- 你可以回去了 - 好 - You can go back if you like. - Okay.
- 约翰 - 巴比叔叔 - John. - Uncle Bobby.
他们只准亲人探病 They wouldn't let me in unless I was family.
- 这是给小孩的 - 谢了 - Some things for the kids. - Thanks.
在睡觉吗？ Sleeping, huh?
嘿，谢谢你来访 Hey, thanks for coming.
我是医学家，必须追踪实验结果 I'm a scientist. Gotta track the experiment.
真希望你的酶能通过实验 I wish your enzyme was the one that passed the test.
但孩子们注射的是对的吧？ 我是说… But the one the kids are getting, it's the right one, right? I mean...
这能帮助他们 It's gonna help them.
大家都已经尽力了 Yeah, you guys have done everything humanly possible.
我们只能看看测试结果 We just have to see what the tests show.
你和我常常意见不合 You and I have had our differences,
但我只想让你知道一件事 and I just want you to know something.
我要你知道… I want you to know that...
- 是的 - 别打岔 - Yeah. - Don't interrupt.
好 Okay.
我要你知道我很感激 I want you to know that I appreciate everything
你对梅根和派屈克所做的一切 that you've done for Megs and Patrick,
我这辈子永远不会忘记 and I'm never gonna forget it for the rest of my life.
他不会亲我吧？ Not gonna kiss me, is he?
我会阻止他的 I will restrain him.
别引诱我 Don't tempt me.
爸爸爱海绵宝宝 爸爸爱海绵宝宝 Daddy loves SpongeBob, Daddy loves SpongeBob.
- 住嘴！ - 爸爸爱海绵宝宝 - Stop! - Daddy loves SpongeBob.
小朋友？ Guys?
怎么了？ What's going on?
什么事这么好笑？ What's so funny?
你们在笑什么？ What are you laughing at?
你们在笑什么？
糖 Sugar.
是糖引起的兴奋 It's a sugar high.
酶分解了他们肌肉里的糖 The enzyme's breaking down the sugar in their muscles.
- 这药有效了？ - 是的 - The medicine's working? - Yeah.
约翰 John.
梅根！ Megs!
嗨 Hi.
- 约翰，小心开！ - 兜风愉快！ - John, drive safe! - Enjoy the ride!
梅根和派屈克的"特效药" Rock and roll!
解除了器官扩大的危险性 拯救了他们的性命
摇滚吧！
- 拜！祝愉快 - 拜！ - Bye! Have fun. - Bye!
夏天来临时
梅根自幼儿时起 第一次能挺挺地坐在车里
约翰全力开发 庞贝氏症第二代药物
以及其它基因疾病药物
梅根强烈要求下一个药 务必是粉红色的
在约翰的协助下 梅根坦伯是首批拿到药的人
在她三岁时，她学会走第一步路
太好了！ Yes!
好耶！好耶！
婴儿时期投药
就能终身控制庞贝氏症
最近的实验结果显示
史东希尔博士的医学理论是正确的
史东希尔生技公司
他兑现了支票