大家早上好，我叫Anil Sadarangani
Good morning to everyone my name is Anil Sadarangani
以及Symbox的首席执行官
And the CEO of Symbiox
我们成立了公司
We started our company
差不多六七年前
A almost six seven years ago
在美国
In the us
我们想，我们有一个很大的任务
And we wanted to , we had a big mission
我们想开始治愈慢性伤口
We wanted to start healing chronic wounds
我们是生物科技公司
We are biotech company
一直在做研究
That has been doing its research
你看到了吗
You've seen photosynthetic
我将在一分钟内解释的合成解决方案
Synthetic solutions that i will explain in a minute
什么是慢性病
What are chronic
慢性伤口是指无法愈合的伤口
Chronic wounds are wounds that fail to progress
在不同的治疗阶段
The different faces of healing
伤口从不愈合
And there they never closed
市场对此非常感兴趣
The market is very interesting
据报道，在2017年的全球市场大概为
Two thousand seven twenty seventeen was reported to be a market of around
每年24亿
Two point four billion per year
只是
Just
如果我们专注于目前的伤口护理管理市场
If we focus on the current wound care management market
根据美国和欧洲的研究
According to studies in the US and europe
我们大约有一千万人受到影响
We have around ten million people that are affected
每年关于这些伤口
Every year about these wounds
你可能知道糖尿病溃疡是最常见的（慢性伤口）
And as you may know the diabetic ulcers are the most common
在过去五年中，亚洲是最大的增长市场，尤其是中国和日本
Asia is the biggest growing market through the last five years especially china and japan
当然还有其他驱动因素，例如肥胖和糖尿病
There is Of course other drivers like obesity and diabetes
这一数字占该病例全球增长率的7.5%
That account for a seven point five percent of global annual growth rate in this disease
我们知道的最主要的慢性伤口问题之一是糖尿病的溃疡
One of the main chronic goons that we know are the Diabetes ulcers
他们的问题是没有真正的治疗方法
And the problem that they have is there is not a real treatment
可以治愈伤口
That would heal the wound
其中大部分都会导致
And most of them we generate unpaid
组织坏死甚至截肢
No regeneration of course amputation
甚至是患者的死亡
Or even the death of the patient
这些病人的主要问题是他们没有正确的治疗方法
The main problem for these patients is that they don't have the correct
无法产生氧气并输送到一侧（伤口）
oxygen and delivery to the wounds side
据报道，氧气对伤口愈合过程非常重要
And it's been very well reported that oxygen is very important for the wound healing process
那么，我们如何产生氧气呢？我们利用大自然母亲和水的合成过程
So how do we generate oxygen？ we use mother nature and we use the process of water synthetic
这就是我们开发合成支架技术的方法
And that's how we develop our technology which is for synthetic scaffolds
在那里我们运用了组织工程的专业知识
In where we used our tissue engineering expertise
再加上光合作用的过程
Plus the process of photosynthesis
以及我们使用微藻的地方
And where we use micro algae
把氧气直接送到伤口
To deliver oxygen directly into the wound site
这是一个小视频，显示了一个标志性的慢性伤口
This is a small video that shows a chronic wound
当你使用我们的产品
When you apply our product
然后我们还有一个照明设备可以产生它
And then we also have an illumination device that would generate it
当然要加倍
Double of course
让敷料能够产生氧气
Have the younger generation option in order to
恢复伤口
A recover the Wound
我们当然会开发自己的照明设备
We of course develop our own illuminating device
特别是
That specifically
它能够产生使敷料产生氧气
Is able to generate the oxygen coming from the
这是一张诊所使用的设备的图片
This is a picture that shows the device using the clinic
正如你所看到的，我们使用一个特定的led灯
As you can see we use a specific led lights
在那里你可以记录温度
And where you can have recording of the temperature
以及你不会暴露的光的强度
And intensity of the light you won't expose
当你打开它的时候
And when you turn it on
这就是它的工作原理
This is how it works
在病人体内
In the in the patient
所以我们的技术的竞争优势是生物降解
So the competitive advantage of our technology it's biodegradable
一旦伤口开始恢复，你不需要移除
Once the wound starts recovery you don't need to remove
它们是矩阵（与皮肤融合）
They matrix
这是安全的，我会给你看临床模型的数据
It's safety and i'll show you data in clinical models
实际上在实际模型和一些病人身上
Actually in practical models and in some patients
当然我们什么都有（专利布局）
Of course we have everything covered by US
拥有美国和欧洲专利，现在我们开始进入中国
And european patterns and now we're starting to enter into china
当然，我们已经看到了愈合闭合和质量的改善，医生或护士很容易使用它
And of course we've seen improvement healing closure and quality and it's very easy to use with doctors or nurses
目前市场上的解决方案非常糟糕，因为它们都是
The actual solutions out there are really bad because they're all
产生姑息治疗没有一个产生伤口愈合恢复
Generate palliative treatment none of them generates the wound healing recovery
这张表再次总结了不同的解决方案
This is a table that summarises the different solutions again
但最重要的是
But the big important thing is that
一个也没有
None of them
局部释放氧气
Release locally oxygen
当然没有一个
And of course none of them
治愈伤口
Heal the wound
当然，我的的解决方案是
An our solution of course
三个月或六个月的治疗时间，我会给你看数据
In three or six months you start , i will show you data
但你开始看到恢复
But patience you start seeing recovery
并且成本非常低
And below and is very low cost to generate the micro
我们已经在小鼠和小猪身上做了所有的临床前验证
We've done all the preclinical validation in mice and pigs
遵循美国FDA的所有要求
Following all the FDA requirements in the US
两者都有
And with demonstrated both
我们产品的安全性和有效性
Safety and efficacy of our product
值得一提的是，我们使用的微藻
It's important to mention that the micro algae that we use
它被认为是草，基本上是安全的
It's considered grass which is basically safe
美国食品和药物管理局（FDA）
For the FDA
我现在要向你们展示一些我们试验时所做的数据
I'm going to show you now some data that we have done in our twinkle
当然是注册
Which is of course register
在内部网站
In the inner h website
这是20个病人的第一阶段
These are phase one for twenty patients
这就是我们对病人伤口的临床顺序
So this is the clinical sequence we have the wounds of the patients
当然要测量了
Your of course do the measurements
我们在实验室里做支架
And we create our scaffolds in the lab
遵守所有规定
Following all the regulations required
一旦他们把辅料（光合支架）运到手术室
And then once they scaffolds getting to the operating room
医生能够
The doctor is able to
他想怎么剪就怎么剪
Cut as he feels like
当然还有介绍
And of course introduce
显微镜将我们的解决方案植入带入伤口一侧
The microscope the our solution into the wounds side
然后把它缝合起来
And then cover it up
使用我们的照明设备
Use our light device in order to
让微藻能释放氧气并治愈伤口
The micro-algae to liberate the oxygen and heal the wound
这是一个肘部有疤痕的病人
This is a patient that had a scar in his elbow
他动不了
And he couldn't move it
所以我们把所有的组织都取出来
So we remove all the tissue would carry it out
我们用敷料
And we use our scaffolds
三个月后他有了一个完美的皮肤
And after three months he had a perfect
他能靠着胳膊和胳膊肘移动的计划
Scheme where he was able to move against his arm and his elbow
这是个糖尿病溃疡病人
This is a diabetic ulcer patient
我很抱歉，为了这张照片
I'm apologize show that for the image
但这是一个永远无法治愈伤口的病人
But this is a patient that could never heal this wound
他的脚趾被去掉了
He had his toes removed
我们用我们的产品做了一个特殊的手术
And we did a specific surgery with our products
两个月后，他又痊愈了，伤口仍然愈合
And again after two months he was fully healed and his wound still stays close
正确，我们现在使用可生物降解的基质
Correct we using now a biodegradable matrix
但它被身体吸收了
But it's it's absorbed by the body
所以你不需要移除它，因为如果不是，你会移除它
And so you don't need to remove it because if not you will
中断伤口愈合过程。我们的敷料仍留在伤口里，你不需要触摸它，它会被吸收
Interrupt the wound healing process so our matrix stays on the room you don't need to touch it it will degrade automatically
我想你之前提到过我们的专利已经涵盖了一切
I think you mentioned before we have everything covered with our patents
我要说我会说这是我们的母版模式
I need say i will say it's a mother patterns where we have
如果我们用掩护，应付所有不同类型的敌人
Cover all the different type of aggies if we use cover
如果我们用凝胶胶喷一种声波形式和基质一种组合
If we use gel glue spray a sonic form and matrix a combination
当然了，你用感染来治疗药物
You were using infections for medical use of therapeutics of course
我们不会掩盖我们的模式
We will not have covered our patterns
当然，我们也讨论了其他用途，如三维生物打印
And of course we've also covered other uses like three d bio printing
或者我们想在将来替换红细胞，这样一切都会被覆盖
Or we want to replace red blood cells in the future so everything is covered in
我们现有的自由模式
The free patterns that we have current
授予
Granted
我们当然也有二十多种出版物
We also half of course a more than twenty publications
我只展示了其中的一些，如果你感兴趣，请发送链接给你，你可以下载我们的所有文章
I'm showing only some of them and if your interested and send you the link where you could download all of our articles
我们两个还都致力于产品的商业运输
We both also work on the commercial shipment of the product
在过去，我们已经能够做一些实验
In we have been able to do some experiments
所以基本上
So basically
他们保存的很好
Sleep they mr
所以我们可以让他们当天直接送到诊所
So we can have them delivered directly to the clinic the same day
无论患者是否需要它，我们能够长期保存
Does the patient needs it so we are able to extend
生产大约需要六个月
The production like to six months
这是我们的团队，我是博士和MBA
This‘s the team , i'm used to the phD and MBA
在美国，我们的所有知识产权都由我们的合作伙伴卡特琳娜瓦伦西亚和普罗科皮奥负责
We have all our ip taking care in the us by our partner katerina valencia and the procopio
律师
A lawyers
我们的总运营官
Our general operating officer
当然还有我们的医疗团队和科学家托马斯，他们开发了这项技术
And then we have of course our medical team and our scientists thomas who develop the technology
但是教给我，他问
But teach for me and he asks
这是公司的一段历史
This is a little bit of the history of the company
我们已经能够筹集近200万美元的非释放资金，基本上是通过赠款
We've been able to raise almost two million dollars in non delivery funding basically with grants
我们有了第一笔私人投资
We had our first private investment
大概在三年前
almost three years ago
现在我们要筹集一百万美元的资金
And now we're looking to raise a one million dollar funding
为了完成临床试验，开始新一轮的研究
In order to finish the clinical trials and to start a phase
在美国与中国的一些合作伙伴合作
With some chinese partner in china in the US
当然，我们在国际上得到了一些认可，在美国，当然在智利
And of course we had some recognition internationally in the US and of course in chile
这是我们过去几年获得的一些奖项
And this is some of the awards that we've been getting the last couple of years
最后，我今天展示的只是投资组合中的一个项目
Ok and finally what i show today is only one of the projects of the portfolio
为了利用微藻保存器官，我们也在进行临床前研究
We are also doing preclinical studies in order to preserve organs using microalgae
所以基本上，当一些病人死了，他们不得不捐肾
So basically when some patients die and they have to donate delivers of kidneys
我们可以在更多的时间里使用微型计算机来维护kingly的控制杆
We're able to maintain those levers of kingly for more time using the micro
而且在癌症治疗中，当你使用选择性比放射治疗更有效
And also in cancer therapies when you use option is more effective than radiation therapy
我们还有两个项目
So again we have two projects
有一点点
Which are a little bit
更不成熟
More immature
我们正努力在公司发展
And we're trying to develop in the company
非常感谢，如果您有任何问题，我很乐意回答
Thank you very much and if you have any questions i'll be happy to answer them