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hi everyone thank you for joining us here today we're so grateful to be here
with so many friends and partners as we announced our next major initiative will
be investing in basic science research with the goal of curing disease
as a doctor this is something I've been thinking about for a while
in fact the last time I was in this room was in 2008 and Sam ha good gave me my
first white coat since the first time we've gathered to talk about the
Chancellor bergen initiative
I'd like to take a step back and talk about how we think about our work
one year ago my our daughter max was born and we launched the Chancellor
bergen initiative with the goal of dramatically improving the lives of all
those in Max's generation our mission is ambitious advancing human potential and
promoting equality we want to dramatically improve every life in Max's
generation and make sure it we don't miss a single soul we reach every
individual we asked ourselves in our children's lifetime is it possible for
them to learn a hundred times what we do today can we ease the suffering of many
by curing preventing or managing all diseases that affect us now these are
big questions and they're incredibly personal for me i'm the daughter of
chinese vietnamese refugees my parents didn't come to this country with much
and they try their best to navigate this world my mother was here worked
she worked long hours and multiple jobs to make sure that my sisters and I had
the best opportunities possible my family believed in education but didn't
understand the school systems so they trusted our teachers with my sister my
future those teachers instilled in me a passion for learning and particularly in
science I brought that to life but designing my own science classes and
being on the robotics team i have to tell you
robots change my life way before it was cool to even think about a robot
changing your life that love of learning carried me to Harvard where I realized
that something incredibly special had happened as a child of refugees and
first generation to go to college I had ended up in a place with incredible
seemingly limitless opportunity and that wasn't available to everyone else there
I would study neurobiology Spanish and eventually attend Medical School
realizing that i was incredibly lucky to be where I was sparked and continues to
drive me to ensure that others regardless of background can have their
opportunity to reach their dreams and their full potential in college I let an
after-school program very close to where I grown up our official job was to help
the kids with their homework but in reality we did whatever we needed to do
to give those chant kids a chance to thrive those kids were the sole of my
college experience one day a school counselor came to me looking for a
student that had missed several days of school I haven't seen her either but I
agreed to go help find that student and see what was happening after program
that day I stepped out and went to the playground and found her immediately
I saw why she hadn't been to school her two front teeth were broken and she was
ashamed to be seen my heart and mind were flooded with questions what had
happened to her was she hurt her her teeth infected what could have I have
done to prevent this that last question crushed me it
the question is simply simple but the answer is so complex that i had no tools
to tackle that question drove me to medical school to help expand my toolbox
of skills to help children all children thrive overtime my work as an educator
and as a pediatrician has led me to think bigger about what's possible what
can we do to enable max and every child in her generation to exceed all of our
dreams of what we currently think is possible we began tackling the mission
of the Chancellor bergen initiative advancing human potential and promoting
equality through education
mark and I immersed ourselves in the world of education learning from the
best minds and experts on the front lines of how we could best make an
impact for every child to be compassionate about learning and to
learn more than we ever thought possible after six years of learning and
iterating we believe that personalized learning can help us reach that goal
personalized learning recognizes that children all have different needs
academic physical and emotional well-being learning styles and interests
by building new tools and systems we can give students ownership over their
learning access to resources that really resonate with them and opportunities to
see their learning come to life at the primary school
we're doing that for the early childhood in elementary world integrating health
development and parental support
as of yesterday we are now serving more than a hundred families
in the middle school and high school world were helping build a number of
school models and tools to help children build their core knowledge and skills in
a way that best suits them somewhat public schools is a great example of
this as of this fall they're serving more than 20,000 students in over a
hundred schools nationwide
and outside of the traditional classroom we're investing in companies like bayous
that's giving 250,000 students access to incredibly high-quality materials to
augment their in school learning now max is too young for all this right now
wait for it
she's 10 months old and the pediatricians in the room i'm very
concerned she's not making her
mmm sounds yet so mark and i spent a lot of time talking about Max and Mama and
Mark dad we believe in the power personalized learning and that we can we
uniquely contribute by supporting leaders in building modern tools to help
teachers and learners reach that vision we're looking forward to ship sharing
more in the future so that's what we've been up to but today we're going to talk
about our next initiative curing diseases as a pediatrician I've worked
with families at their most difficult moments of their lives from making a
devastating diagnosis of leukemia to sharing with the family that we were
unable to resuscitate her child in those moments and many others
we're at the limit of what we understand about the human body and disease the
science behind medicine the limit of our ability to alleviate suffering we want
to push back that boundary by investing in science today we hope to build a
future in which all over children can live long and rewarding lives
when we decided to tackle this second focus area we started asking questions
mark and i spent the past two years talking to scientists ranging from Nobel
Prize laureates to graduate students we've learned a lot and we know that we
have a lot more to learn
we believe that the future we all want for our children as possible we set a
goal
can we all together work to cure preventer manage all disease within our
children's lifetime that doesn't mean that no one will ever get sick but it
does mean our children and their children should get sick a lot less and
when they do we should be able to detect or treat it are at least manage it as an
ongoing condition market invite but mark and i believe that this is possible
within our children's lifetime as we talked to a lot of top scientists we
realize that they do too
of course we can't do this alone so today we're partnering with scientists
doctors engineers and universities to achieve this goal
our aim is to bring together teams of innovative scientists and engineers to
build transformational tools unlock new era of accelerated progress in science
and health for this initiative will be investing more than 3 billion dollars
over the next decade to achieve our collective mission
yeah
great efforts take great leaders and today we're pleased to welcome dr. Corey
bargain as the incoming leader of chance occurred science
those of you not in science may not know Corey yet but scientists in this room
just got really excited
Cori Bargmann is a legitimate rockstar she's one of the world's most respected
neuroscientist and geneticists and recently led the president's brain
initiative
Coris job will be to build out the strategy and partner with academia
biotech and engineering to help realize this vision we couldn't be more excited
to have her leaving this work and corey mark and I are also excited to announce
our first science investment the bio hub we're investing six hundred million
dollars to bring together leading scientists from Stanford Berkeley and
ucsf along with a world-class engineering team to help us develop new
tools to understand and treat disease the Bible in a building just blocks away
from where you're sitting right now the bio but we led by joe torre see a
biochemist known for his genomics approach to infectious-disease ranging
from the deadliest form of malaria to a wide range of viruses and Steve quake a
biophysicist and bioengineer who developed a number of measurement tools
to help us better understand health most notably replacing amniocentesis with a
blood test
we're so excited to see what they accomplished the bio hub with their
focus on bringing its scientists and engineers together to help build tools
for the entire scientific community we've met
we've met some amazing people on this journey and we're so thankful that so
many leading scientists are joining us as advisors and partners in this new
science initiative and for the bio hub tackling all disease is a big goal and
we're so excited to work with all of you to achieve it
now hand it off to mark my partner and all things ranging from bath time to
understanding science
yeah
I love her
she is so inspiring sun sparc before we get started before I get started I just
want to thank all of you for coming out today I'm looking out and I see our
family and so many close friends who have traveled from all across the
country and a lot of people who've worked with for many many years and I
just want to say it's really meaningful to me and Priscilla that you're here
with us this is something that we've been working on for for a few years now
and we're really excited to share with all of you today so thank you
when Max was born we wrote this letter describing the hope that she gave us for
the future and I know that that's a hope that so many of us here
share that we can make a better future for our children and for generations to
come
Brazil is a doctor i'm an engineer and I think that that hope is part of the
engineering mindset right it's this belief that you can take any system no
matter how complex and make it much much better than it is today whether it's
code hardware biology company and education system of government anything
you can make anything much much better than it is today so we look for
opportunities to bring engineering to social change because there are lots of
people who can invest capital and hard work but when you can also build tools
when you can empower people to go out in the world and make change for themselves
that's when the biggest change happens and that's what we've done with facebook
to help build a community of more than 1.7 billion people that's what we're
doing with internet.org to help local entrepreneurs connect more than 30
million people to the internet and it's what we're working on with personalized
learning to help give teachers the tools to bring this these new kind of tools to
more than a hundred different schools and two more than 20,000 students in
just a couple of years of work and that's how we hope to help scientists
with this initiative as well so that's our approach here and that's why at the
Chancellor bergen initiative we're building a world-class engineering team
to work on these problems now we went out we started talking to a lot of folks
in the scientific community we were a few themes about how we could be most
helpful we could bring scientists and engineers together to work on problems
in new ways we can build tools and technology that can empower
the whole scientific community worldwide not just right here and we can help to
grow a movement to fund more science to make even more progress and really turn
this into a national mission so those are the three things that we're going to
talk about here today
now let's go to the big question can we cure prevent or manage all diseases in
our children's lifetime or to be a bit more concrete a child born today right
here
what has a life expectancy of right around the end of this century
so can we cure prevent or manage all diseases by the end of this century now
again that doesn't mean that no one will ever get sick but it does mean that
people should get sick a lot less and that when they do we should be able to
identify quickly and treat it or at least be able to manage it as a
non-harmful ongoing condition but this is a big goal and you know we thought
that this was really aggressive when we got started but we've spent the last few
years by going out and talking to dozens and dozens of top scientists and experts
who really believe that this is possible so we dug in and you know we read
everything we can get our hands on I got into the math of of how science is
funded and organized and I got to work with priscilla on this which helped
because she's actually a doctor and she studied neuroscience at Harvard such as
a slight edge on me
slight edge but you know when you when you get into it one of the first things
that strikes you is that medicine has only been a modern science for about a
century to think about that for a second
for thousands and thousands of years we made very little progress on diseases
and then we started treating restored investigating diseases and applying the
scientific method and Ben project about progress takes off
so since then we've eradicated smallpox thanks to some of the people in this
room we
and and we're close to eradicate polio thanks to other people who are here with
us today
we have vaccines to prevent meningitis measles and many forms of the flu
we have antibiotics that can treat potentially deadly diseases like
tuberculosis and ammonia we produced insulin to manage diabetes and statins
to reduce heart disease and chemotherapies to treat many forms of
cancer we reduce smoking through public education and epidemiology and we even
found ways to reduce life-threatening diseases like HIV two conditions that we
can manage on an ongoing basis so all this adds up to finding more and more
ways to cure prevent and manage a more and more diseases overtime now one of my
favorite facts and public health is that if you look back over the last century
life expectancy has increased by about a quarter of a year per year and it's
actually been pretty linear the progress and this is due to advances in science
and public health so if we can only continue this trend through the end of
this century then by the end of the century the average life expectancy will
be right around a hundred which implies that we will have found cures or ways to
solve most of the things that prevent the majority of people from reaching
that age today and you know science and technology accelerate i'm personally
pretty optimistic that we're gonna be able to do a lot better than that now
today most people die from only four kinds of diseases heart disease heart
attacks infectious disease cancers and neurological disease like stroke or
Alzheimer's or Parkinson's and you know of the rest
almost half die from things like accidents and injuries and hunger which
are not necessarily even diseases so if the focus is on curing all diseases
it's pretty clear where you want to focus to start now I really don't want
to over simplify this problem because in each of these categories there are many
different diseases and conditions
then so for example cancer in every different cancers a different disease
and it's unlikely that we're gonna be able to find many single breakthroughs
that cannot get a whole category but at the same time there are definitely
common strategies for addressing each disease each disease category all the
diseases in a given category and common tools and technology that we can develop
to help see and understand and treat the diseases in each category
throughout the history of science most major scientific breakthroughs have been
preceded by the invention of some new tool or technology that allows you to
see an experiment in new ways right so the telescope but let us see planets and
and stars and let us to build understand astronomy and the universe the
microscope let us see cells and bacteria and let us to be able to treat malaria
and pneumonia and opened up whole new field of study or more recently DNA
sequencing and now editing allows us to explore our genomes and more precisely
fight cancers and a whole lot of different genetic disorders tools also
create breakthroughs and how we treat diseases so vaccines are a broadly
applicable tool that we can now rears and build upon to treat a certain
prevent more and more different kinds of diseases overtime so you look at this
and it's actually pretty easy to imagine what new tools we need to develop to
make progress on the four major disease categories that we just talked about AI
software to help with imaging the brain which we really need to push our
understanding of to make progress on neurological diseases or machine
learning to analyze large databases of cancer genomes a chip to be able to
diagnose any infectious disease continuous bloodstream monitoring to be
able to identify and catch any disease early or a map
of all the different kinds of cell types in our bodies and the different states
that they could be in so that people are designing drugs can reference that too
quickly design something for any given disease that's out there so these are
the kinds of tools that we want to focus on building at the chance Zuckerberg
initiative and more broadly this focus on building tools suggest a roadmap for
how we might go about curing preventing and managing all diseases this century
because if we can help develop the new tools that allow us to see these new
these categories of diseases and new ways and experiment then we can empower
scientists all around the world to make much faster progress and breakthroughs
in these areas
now building tools requires new ways of funding and organizing science because
when you look at it today our current funding environment doesn't really
incentivize that much tool development right the the typical scientific grant
is a small granted maybe a few hundred thousand dollars which is enough to pay
a few signs of salaries or maybe four part of the lab but it's not enough to
do serious tool development right because tools often take large groups of
scientists and engineers working together over long periods of time so
this is a sketch of one of the first internal combustion engines which was a
collaboration between many scientists and engineers over decades and when this
was created it led to the invention of cars and planes and a lot of things that
are staples of our modern society but this was a large investment a really
large scale collaboration and it took a long time horizon for this to happen so
this brings us back to our plan solving large problems requires bringing
scientists and engineers together to work in new ways to share data to
coordinate and collaborate and in most science funding today goes to
individuals working separately so what we've heard is that there's a big
opportunity for us to invest in projects that help to bring people together
tool development has always had a big part of engineering and today that
increasingly means software engineering but in today's funding environment it is
really hard to have a large group of world-class engineers like the kind that
you'd find a great technology company today working on these kind of problems
and of course that's exactly what's required for developing a lot of modern
tools so this is going to be one of the biggest focuses for us at the Chancellor
bergen initiative and we're also going to support long-term initiatives because
you know I think we all know hear that the biggest breakthroughs take many
years and we want to make sure that more scientists in the community have that
long term time horizon to be able to pursue their ideas and work to prove
that their ideas can can work out of a long-term now we also want to help push
for more science funding overall our society today spends 50 times more
treating people who are sick then we spend trying to find cure so people
don't get sick in the first place we can do better than that you'd only invest
that way if you believe that people were always gonna get sick or then you try to
treat people as well as you could and you just hope that science improve some
things on the margin that's what investing 50 times more and treating
people then try to find cures looks like but in a world where we can actually
cure all diseases in our children's lifetime our society should invest
dramatically more in this and there are so many opportunities for governments
especially but also nonprofits & and companies to invest more in science and
carrying diseases and to investing tools to empower the whole scientific
community worldwide to make more breakthroughs so this is an area where
public support really matters right because the more people who believe that
we can cure all diseases in our children's lifetime
the more likely we are to get our governments to investment and the more
likely it is to actually happen so this is something that we can all come
together and where we need your help and it's an area where we can all do
something really important together now to summarize again from all the
conversations that we've had with with dozens and dozens of scientists and
experts in the community there are three big opportunities that we want to go
after want to help bring scientists and engineers together was a massive
opportunity to do that to work together in new ways there's a huge opportunity
to build tools and technology to empower not just the folks working here at the
bio hub and in the bay area but across the whole world there's a big
opportunity to build a movement to help fund more science around the world
that's the plan
right
thank you
so this is what we're going to focus on for the rest of the presentation
in a minute Corey is going to come up here and she's going to talk about how
we're building networks to work on these different kinds of diseases around the
world like we're doing right here with the bio up and then right after that
steve and joe are going to come up and talk about the work that we're doing
right here at the bio hub in areas like infectious disease and a new tool called
the cell atlas
now remember this is going to be a long-term effort where we're going to
invest billions of dollars over many decades but it's gonna take years before
the first tools get built and then years after that before they're actually used
to cure diseases so we have to be patient
this is this is hard stuff but it's but it's important and you know I think that
this is about the future that we all want for our children are because if
there's even a chance that we can help to cure all diseases in our children's
lifetime that our children are even their children can live happier
healthier lives then we're going to do our part and together we all have an
opportunity to leave the world a much better place than we found it so thank
you for coming out today it's really meaningful to me and Priscilla that
you're here with us and now it is my pleasure and honor to introduce the
world-renowned expert in neuroscience and genetics the leader of Chan
Zuckerberg science dr. Corey bargain
yeah
so it's very exciting to be standing here today for those of you who don't
know me I'm a geneticist a neuroscientist i had the privilege of
taking part in a spectacular area of biology and I can't imagine a more
thrilling experience
science is one of the great accomplishments of humanity it
represents the efforts of many thousands of people working over hundreds of years
who have built on each other's discoveries to learn about how the
natural world works
it's fascinating it's beautiful and science is also useful as a biologist
I've seen firsthand discoveries that have led to advances in human health my
scientific career started in cancer biology not treating patients but trying
to understand what makes cancer cells different from other cells in the body
discover i may I made is as a graduate student about a obscure rat cancer was
one of many steps made by many people that ultimately led to the development
of Herceptin a drug used to treat human breast cancer Herceptin was the first
drug that was pointed like a laser at exactly the genetic changes that caused
a cancer cell to grow as a student fumbling along i would never have
believed that this would result in part from my work but over the years I
watched many scientific discoveries lead to medical progress and i'm here to tell
you today that it does happen basic science works
and that's important because we have great unmet needs in medicine in my own
field of neuroscience for example there are far too many brain disorders for
which we don't have any viable treatment disease is not just about death
it's about human suffering brain disorders like autism or schizophrenia
or Alzheimer's disease prevent people from living full lives in the time they
have they will affect someone in every family over the course of a lifetime and
the same goes for many chronic diseases we need to do more
Priscilla and mark through Chan Zuckerberg science want to inspire and
support the science that will allow us to cure prevent and manage all major
diseases by the end of the century
that's a heart-stopping statement and it should be what does it take to make that
a reality
well we're talking about curing preventing and managing diseases by the
end of the century 80 years from now that means we can look at projects will
pay off in 20 years or in 50 years to me that long view is what makes Chan
Zuckerberg science initiative feasible and that's why market Priscilla's vision
resonated with me and makes me want to make it a reality taking the long view
the scientific discoveries that have led to major medical progress have common
themes first they're made by extraordinary people second they're
often spurred by advances in technology that allow a question to be asked in new
ways third the big advances usually involve people with different skills and
backgrounds working on a common problem these three pieces people technology and
collaboration are the theory behind Chan Zuckerberg science how does that theory
look in practice
well we have a plan
we will build bring different kinds of scientists together with engineers in
new ways we will build tools for everyone to empower the entire
scientific community and we will work to grow science and science funding so more
science happens today I will talk about those first two areas and give some
specific examples of the kind of projects we're going to do the bio have
transformative technologies and challenge networks our first investment
a chance Zuckerberg science is the bio hub which we are also thrilled to
announce today the bio hub here at mission bay is a new partnership between
three great universities that have not cooperated formerly this way in the past
yeah
ever
at the bio hub basic scientists physicians scientists and engineers will
develop new technology platforms and apply them to biology and medicine it's
being led by two exceptionally inventive people of biologists Joe jury see and a
physicist turned engineer Steve quake both have amazing accomplishments Steve
to develop the prenatal blood test for learning the fetus has Down syndrome
with that amniocentesis and Joe is made important progress in studying diseases
in the headlines like the SARS virus as well as long-standing diseases like
malaria which infects 200 million people worldwide Steven Jo will tell you more
about the bio hab which perfectly represents the principles we want to
support scientists and engineers transformative technology and
collaborating on important problems
the second piece of Chan Zuckerberg science is building tools to empower the
entire scientific community transformative technology we are at a
time of incredible opportunity right now with new computational tools like
machine learning and new biological tools like genome editing and stem cells
a chance Zuckerberg science we want to improve those tools scale them up and
put them into as many hands as possible so that every scientist can do the best
experiments and we want critical mass so we'll be working with external partners
and with funding agencies around the country and around the world for example
there's a growing interest in the scientific community in the idea of a
cell atlas a comprehensive resource with the locations numbers and molecular
properties of all of the different cell types in the human body
we need this information to develop new understanding and cures for areas for
diseases in all areas of Medicine we're going to advance these areas by
supporting technology development at the bio hub but also by supporting them
collaborating with partner
efforts throughout the scientific community we have other projects in mind
like building our founders unique insight into software engineering into
more sophisticated databases and data interrogation tools and developing
engineered human stem cells for studying the cell biology of every major human
disease and importantly everything we develop every tool every piece of data
every cell line will be available to all scientists everywhere
the third piece of Chan Zuckerberg science is just support networks of
external investigators with a common mission across the u.s. and eventually
around the world who will work on important problems in a cooperative way
I think of them as virtual Institute's we're calling them challenge networks
here's the idea and an example an important unmet need in my field is
better treatment and prevention for neurodegenerative disease there's also
an incredible opportunity for the first time because we know many genetic risk
factors now for human diseases like Alzheimer's disease or Parkinson's or
ALS but we don't know what these genes actually do to those brains we don't
even know half the time whether the gene is acting in a dying cell or in some
bystanders cell so in the perfect world we take the most insightful physicians
and the deepest mechanistic cell biologists to dig into those risk
factors and the cleverest engineers building miniature microscopes and
solving pattern recognition problems in brain biopsies and tell them to talk to
each other and learn from each other how to answer these questions and that is
the idea of a network a group of 10 or 15 labs with different expertise working
on a common challenging problem Chan Zuckerberg science will select the
network members support them bring them together for physical meetings and
create communication systems so that they learn from each other as part of
this virtual Institute I have to tell you in the past few years I've spent far
too much time and hospitals with people i love when i listen to their dedicated
doctors I've realized that there is so much that we don't understand and so
much science that needs to be done
that's what we want the network's to build out we envision networks that will
be focused in some cases on individual diseases in some cases on technology
development and in some cases on important biological areas that will pay
off in the long term
why neurons die in neurodegenerative disease how viruses bacteria and
parasites cause disease how the immune system attacks viruses without attacking
the body how the chemistry electricity and wiring of the brain work together to
generate thought and emotion if you take great people and set them loose on
important problems in an intelligent way and give them a long time horizon there
will be progress we want people committed to the mission and a strong
collaborative interactions one component of that will be supporting a different
career model where we fund highly-qualified hands-on working
scientists and engineers working within the network labs and within the
technologies and in the bio hub and we will build a reward and incentive system
that encourages them to work together over the long term we hope these
scientists early in their careers will build a new culture of scientific
collaboration and this is really exciting to me
the importance of technology the importance of collaboration the need for
new scientific mechanisms and career tracks these are bottom-up ideas from
the scientific community they're already refined by discussions with many people
and they will be refined further we're being guided by a spectacular scientific
advisory board and these are people who all have great accomplishments both in
science and in leadership and several of them have come from around the world to
join us this morning and I could ask you to stand up but just to tell you who's
going to be with us
it includes art Levinson who does not be Bob teaching David house
Fleur Shirley Tilghman to be a spawn Hoffer and harold varmus thank you for
your thoughts thank you for being here
and then just to be really clear at every point in Chan Zuckerberg science
will be asking expert scientists and engineers to help us identify the right
project select the right people and evaluate them going forward in the bio
hob ucsf berkeley and stanford are our partners they're taking a risk to do
something they've never done before Chan Zuckerberg science will be looking for
other partners for the transformative technology projects and for the
challenge networks that doesn't mean more physical bio habs it means partner
institutions and scientists to share our vision and are willing to take the risk
of trying out new collaborative scientific models that bring together
scientists and engineers build tools and reward people for working together
across boundaries and institutions so in summary
here's what we want to do find great people and support them let them work
together on important problems and technologies give them a long time
horizon this will work
and with that I would like to introduce the co-presidents of the bio hub Steve
quake and Jojo Ricci and first up Steve quake from Stanford University thanks
Cory I let me open by saying what a pleasure and an honor it is to be here
today
my name is Steve quake and i'm a professor at Stanford University and
co-president of the by Hubble along with my partner Joe Torre see who you'll be
hearing from shortly the bio hub is dedicated implementing the chance
Zuckerberg science mission from the perspective of technology development
and scientific discovery
we've partnered with Stanford UCSF and berkeley in order to support and harness
the spectacular talent that those three institutions in the service of
developing new technologies will help cure human disease the bio hub is going
to pursue large interdisciplinary problems problems which can't be solved
the conventional academic environments and do not fit in a government funding
models
we're also going to provide support for individual faculty members at those
three universities to pursue their riskiest and most ambitious ideas in
order to help invent the next great generation of technologies
finally we're going to provide access to the technology platforms based on by of
inventions to all the scientists and medical research of those institutions
so they can be used to broadly advanced scientific and medical research going on
there as you heard we have a very strong engineering paradigm both internally at
the bio hub and in the faculty that we supported the universities and that's a
unique in distinguishing aspect of our program mission shows going to go into
more detail about our plans you hear about that in a few minutes we're
fortunate to be advised by some supremely accomplished engineers
physicians and scientists and I want to take a moment to introduce you to some
of them are external scientific advisory board
foods rick lifton president Rockefeller University and sangeeta bacha is a
distinguished professor of bioengineering at MIT
it also includes bobcaygeon former president howard hughes medical
institute and Don gam who's the head of global infectious disease and Novartis
we've also got an internal advisory group with representatives from each of
the three participating universities and includes Russ Altman from Stanford
Jennifer down from berkeley and jonathan weisman from ucsf none of this would be
possible without support of market Priscilla and on behalf of the entire
scientific community
I'd like to thank them for their commitment and willingness to push the
boundaries of science and technology
they're clearly not afraid of risk or ambition and it's wonderful to see that
kind of trust in our plans i'd also like to thank the university leadership and
in particular
John Hennessy and Sam Hall good who were both personally deeply involved in much
of the planning and have also been willing to take risks the bio hub is
unlike anything the universities have done before and both John and Sam have
been very creative and figure out how to design a new sort of relationship
between the by open universities
Joe and I will do our best to deliver on the promise of the bio hub not just as a
place to do great science but also as a place that will change the way science
is done let me tell you a bit about one of our first big projects which is a
Cell atlas of the human body is still Alice will be resource which
comprehensively characterizes not only that many different cell types of the
human body but also provides a detailed architecture of the molecular
interactions within each cell we're going to bring several emerging
technologies to bear on this problem the single cell sequencing technologies
developed by my group and others around the world the power of genome editing
and high-throughput microscopy among others
it's amazing that nobody really knows how many different cell types there are
in the human body the textbooks give a number of about 300 but those of us
working in the field all believe that there are substantially more the cell
atlas will not only answer this question will also provide a detailed molecular
characterization of each cell type and the better we understand these cell
types in health and disease the better we'll be able to develop new therapies
to treat and cure disease in areas ranging from cancer diabetes to
infection is a huge undertaking and we anticipate our efforts will catalyze a
global collaboration among many different groups and institutions to
complete the human cell atlas now I'm pleased to introduce my partner and
leading this endeavor Choudary see
yeah
thanks Steve I am so stoked to be here
I can't tell you my name is Jody Seay i'm a professor here at UCSF and I'm
incredibly fortunate and thrilled to tell you more about the buyout mobile
chemist by training and actually have deep ties to both the University of
California and Stanford so it's natural we should join them together here in the
blob
I like to follow up on Steve's overview of the bio hub with some additional
details of what will actually go on there and how will function first and
foremost the bio hub will be a nexus of collaboration between these three great
powerhouse universities UC Berkeley stanford and ucsf and furthermore the
bow hub will actually have a physical presence is actually located at 499
Illinois just a few hundred yards from where we are right now next to the
Benioff Children's Hospital and that makes it easy access for the various
ucsf campuses around the city for UC Berkeley and for Sanford very
strategically located next to tell you what goes on in the bio hop one of the
things that I'm incredibly thrilled and excited to tell you about today and
something is really near and dear to my heart is the investigator program
beginning october third fact the members from any of the three universities from
any discipline at any career stage through a simple web-based application
can apply for a chance Zuckerberg investigator ship
what does that mean that means a five-year term with a discretionary
budget to pursue your most bold and innovative and risky ideas things that
normal grant-giving organizations would not normally support again we want to
emphasize any scientist from three institutions in any field and we
especially are encouraging early investigators to apply beyond the
investigator program the by Hubble actually maintain and establish a whole
set of technological platforms inside the hub
itself these technological platforms will be the latest in technology but
will also have our own internal engineering team that's going to
actually build the next generation of instruments and and technologies for the
entire community to use regardless of whether your investigator or not now be
on the investigator program and the technology platforms that we're going to
maintain their i'd also like to tell you about the bio hub research projects you
heard a little bit from stephen from corey about the cell Alice project
that's going to really be an amazing project there's another project that i'm
going to tell you about today it's entirely focused on infectious disease
now this is something really near and dear to my heart is what I work on and
they have four major components to this project and they are very simply detect
respond treat and prevent and this really follows about the way we think
about tackling this problem let's cover the first one detect so this is
something that I've been personally invested in for a long time and what it
means is our ability to detect comprehensively in an unbiased matter
any infection from any tissue anytime anywhere
I really got my start in this over a decade ago when we helped assist in the
discovery of the sars coronavirus I'm not really made a huge impression on me
and since that time we've been trying to push these messages as hard as we can
and i believe the technology informatics are at the point now where we can drive
unbiased comprehensive diagnostic testing even from things we haven't even
discovered yet into clinical practice and while this is actually started
already here
the bio hob will work to accelerate and drive these efforts through new tool
development and software engineering next is respond so you don't have to go
too far out of the headlines to figure out why we're talking about this this
point is borne out an incredible frustration on the part of myself and my
colleagues in the scientific community about our ability to respond quickly
two newly emerging threats this has been true certainly for the Zika virus and
will be true for others to unless we do something about it
so while my colleagues here at UCSF and around the world are making solid
progress trying to understand this particular virus and the tissues that
attacks the bio Hubble actually maintain personnel equipment and resources in a
manner that allows us to act very quickly when new threats emerge wherever
they emerge anyhow they might emerge there won't be any long debates about
whether we should find something or not if it's a clear threat treatment
ok no infection is only the first part of the job we have to address this
critical problem that we have a dearth of medications for pathogens especially
viruses and what the Bible hub will do is leverage advances in high content
imaging and screening as well as the cell atlas and crisper gene editing
tools to better find identify exploit both host and pathogen targets for
therapeutic interventions and help develop those with our partners around
the world and in California especially now the final one is prevent so the
ultimate Arsenal in preventing infectious disease is actually immunity
through vaccination
but it is also sobering and it's very much the case that many pathogens have
eluded our ability to confer long-lasting protection the bio hub will
seek to understand the immune correlative protection and to generate
new avenues to actually create the next generation of life-saving vaccines and
i'm thrilled to tell you here today that our colleague down at Stanford peter kim
has agreed to come up to the Bible hob to help lead this effort and he's no
stranger to vaccine and therapeutic development and he will be leading the
charge on this initiative in general it's going to be fascinating to work
with him i'm really looking forward to it
so altogether i believe that the bottle hub is going to accomplish this mission
of bringing the three institutions together to be able to work in a manner
and in a style that they just simply haven't been a mechanism to do before
it's a bold new experiment i'm pretty sure it's going to work better work and
I'd like to thank the support of the universities and made this happen and
especially to mark and Priscilla for their incredible vision and their
dedication to this endeavor this is the
yeah
this adventure has just begun just way now I'd like to call market out to the
stage and thank you very much
alright
thank you Joe and Steve and Cory
I that was a great summary of some of the work that we're going to be doing
here because you're an awesome work already
we're proud to work with you to advance this mission of curing preventing and
managing all diseases in our children's lifetimes now before we wrap up there
are so many people who Priscilla and I want to thank for helping to shape this
initiative i want to start with our science advisors right the dozens of top
scientists and experts who have spent hundreds of hours with us shaping this I
mean this is a lot of different ideas coming together from a lot of different
people and this would not be possible without you so thank you guys for for
that and I want to especially call out a few people who have really invested a
lot of time in this art Levinson had has really helped to organize all of our
discussions and pointed us in the direction of a lot of that the top folks
and most fruitful conversations that we've had so I want to thank art this is
going to be a long list if we clap for everyone but we could get that they
deserve it so it's good on Eric Lander has been an advisor us since the
beginning of this and really has helped Priscilla and Corey and I brainstorm
this idea of having a broad set of scientific networks to tackle diseases
and really the bio hub idea here so I want to thank Eric for for that and
always help along the way
bobcaygeon good news right here who has encouraged us from the beginning to
focus on tool development and probably the first five conversations we had you
just give us all these examples of the different tools that you're building a
genelia farms and inspired us to go in that direction and and bob is going to
be the only member of the scientific community who is on the sign sports for
both the
kanzaki berg science overall initiative and the bio hub so thank you for
continuing to play a special role in shaping this or francis collins the the
head of the NIH really push super hard to focus on computer science and what we
could uniquely bring to this and that really shaped our thinking was a unique
contributions I want to thank Francis for that
who is OB for her really honest and and direct organizational feedback and
thinking on how to structure organizations that do science research
super insightful and and has been invaluable advisor so I want to call her
out
rick lifton the the new president Rockefeller University both for spending
time helping us map out with the bio hope is going to be early on and for so
graciously lending us the time of some of this key faculty members to to come
leave this initiative
thank you Rick and David Baltimore for his wisdom and and kind of encouraging
us to explore different scientific directions
thank you David Shirley Tilghman for helping us explore neuroscience and
importantly introducing us to court this and i'm and and one more
yuri milner our partner in investing in all kinds of different science for many
years and sometimes really help to shape our are thinking so thank you for all of
our science advisors
now that's only one group of the people are going to thank though so I i also
want to call out on the philanthropy side there's a group that has been
particularly helpful the science philanthropy advisors and if some of you
guys today who are here come away from this thinking that you want to get help
invest in science
mark Kastner is the first person you should talk to mark if you're here can
you stand up
yeah he has been so helpful and in helping us think through this and as a
resource and and thinking through how to do this kind of science philanthropy so
thank you
now of course probably the biggest thanks go to Chancellor ha good and
president Hennessy and your team's of course and and Chancellor Dirk's and
your teams at a ucsf Stanford and Berkeley you know there were few jokes
about this but for how great these universities are it's been hard to have
them work together and it took a lot of leadership from from these folks and I
especially want to thank John because in his term as president just just ended
and he ran so hard to this problem to make sure that all the hurdles were
cleared out of the way before his term ended and that is something I will never
forget
so thank you John and Chandler ha good
now there are also some community leaders who are here with us today whose
support and in our community here has been critical to getting this off the
ground so I want to thank the president of the University of California system
Janet Napolitano mayorly mayor shaft and we tend governor Newsome your continued
support and helping to build the community and and making us a place
where we can invest and have the bio have become hopefully one of the great
centers in the world for biomedical research has been extremely helpful and
we really appreciate it
now there's one more person who i want to thank and invite out here to share a
few words and this is someone who has been a role model for me and a mentor
for four decades both in building a technology company and engineering and
more recently in philanthropy and you know this is someone whose work and
eradicated polio and in working on malaria really inspired me and Priscilla
to believe that we could actually cure help the community cure all diseases in
our children's lifetime so please join me in welcoming Bill Gates
yeah
thank you
well thank you Mark and it's an honor to join you all for this incredible
milestone of the chance of coburg initiative is already doing some very
promising work in terms of improving education for all students and so that's
really a thrilling thing and it's amazing that today they're taking on
another bold challenge this idea of turning in and preventing all diseases
by the end of the century
ah that's very bold very ambitious and I can't think of a better partnership to
take it on
glendive have enjoyed getting to know Markham Priscilla over the last few
years talking to them about kids and science and plant being so many things
and what they bring to this is is really kind of amazing you've got marks
risk-taking entrepreneurial skills you've got her understanding as a
pediatrician of of the things that we really need to do and they both loved
science and I'm very committed to where it can take us Linda and I also believe
in science and and we've seen some great progress that these kinds of investments
have led to along before any of us came along science had already done
incredible things for example Rockefeller Foundation and agriculture
has over a billion people living today because of what they did in a plant
science we have all the great people who worked on vaccines and that's a big
reason why in 1990 over 12 million children died and now 25 years later
less than 6 million children die every year and that's science at work but we
need more science i remember during the Ebola epidemic mark was in India and
very concerned appropriately you know
what we're going to do about this and we talked about our frustration that the
science investments to give us the great diagnostics the antivirals the vaccines
they really weren't there and if we had bad luck that could have spread and and
killed tens of millions and we're still at risk not only for that kind of
epidemic but flu and many others and so we need science to go after those tools
so that we can really be safe on saturday i was up in Montreal which was
a gathering to replenish the funding of the Global Fund the Global Fund make
sure that medicines get out to people who need them for three diseases AIDS
malaria and tuberculosis and as people were coming making those generous
pledges they were all saying to me
can we and these diseases you know as generous as those donations were all
they can do is hold the disease and check they are not going with the tools
we have today we cannot end those diseases so only through science can we
get an HIV vaccine or a malaria vaccine or a preventative tool that's so easy
for men and women to use that we get a large-scale prevention and so we
desperately need this science at our work of the foundation it's always
amazing to me what the world doesn't understand about some key issues like
prematurity wire are are some babies born early or even during the first 30
days over a million child children die of infection sepsis and we don't really
know how to stop that as kids grow up nutrition is very important and we're
realizing that the microbiome place a very strong role there but we don't know
enough yet today to stop malnutrition which holds back literally hundreds of
millions of kids and so science is needed and it's a great time I heard a
little bit today about the amazing too
rules that these scientists are using now and sequencing is part of that I was
in a meeting about liquid biopsy last week we're talking about detecting
proteins at ten to the minus 20th at the Zeta molar level and how we can apply
that to things like diarrhea in sepsis and really understand what's going on
there and so it's a magical time to bring this group together to tackle
these problems
Melinda and I started our foundation 15 years going
the thing that's been the most fun for us is meeting other people who share our
optimism and our commitment that the even these top problems can be solved
and at the top of that list are our marketing Scylla their their vision
their generosity is really inspiring a whole new general generation of plant
bus will do amazing things in terms of amazing things the goal we're talking
about today is one of the best i'm so impressed with the team that's been
pulled together here i have no doubt will make great progress on these
diseases and literally not only saved millions of lives but make the world a
more equitable place so i think all of us will be proud to say that we were
here on the day that Marcus illest art of this journey
thank you
yeah
thank you Bill it's incredibly meaningful for Mark myself in this
entire community that you were here with us today I also want to thank everyone
for coming out and launching this brand new chapter of the Chancellor bergen
initiative to help the scientific community cure preventer manage all
disease within our children's lifetime
my heart is full of hope and we are all eager to get started
it's an honor to be with you on this journey let's do this together
yeah Subtitles End: mo.dbxdb.com