1 00:02:21,991 --> 00:02:26,078 All known organisms are made up of cells. 2 00:02:26,078 --> 00:02:30,182 Humans, of course, have lots of them. 3 00:02:31,648 --> 00:02:36,208 Our skin, organs, bones... They are made of them. 4 00:02:36,561 --> 00:02:38,821 Each cell has a nucleus at its center. 5 00:02:39,222 --> 00:02:44,756 Inside they carry a map of each part of our body. 6 00:02:45,253 --> 00:02:48,745 This is DNA, genes. 7 00:02:49,346 --> 00:02:53,086 And there are many more things within each cell. 8 00:02:53,559 --> 00:02:55,615 Every part of it, like the nucleus... 9 00:02:55,616 --> 00:02:58,315 ... has its own DNA. 10 00:02:58,416 --> 00:03:02,326 Its name is: Mitocondria. 11 00:03:03,646 --> 00:03:07,106 The main function of these Mitochondria... 12 00:03:07,106 --> 00:03:09,726 ... is the creation of energy. 13 00:03:11,169 --> 00:03:15,426 But why are the Mitochondria here? 14 00:03:15,779 --> 00:03:17,635 They have their own genes... 15 00:03:17,636 --> 00:03:20,648 so they are also organisms. 16 00:03:28,469 --> 00:03:29,817 Parasites- 17 00:03:29,842 --> 00:03:34,536 A type of lifeform that invades our cells. 18 00:03:34,800 --> 00:03:38,516 (Parasitism) 19 00:04:17,561 --> 00:04:20,361 Mariko! Mariko! 20 00:04:43,744 --> 00:04:44,974 Now... 21 00:04:44,974 --> 00:04:47,045 We will see something very strange. 22 00:04:47,486 --> 00:04:52,646 Humans inherit properties such as character or appearance. 23 00:04:53,199 --> 00:04:56,445 But the Mitochondria are only transmitted by the mother. 24 00:04:59,085 --> 00:05:03,148 The Mitochondria that each one of you carries in your body... 25 00:05:03,415 --> 00:05:05,788 All of them come from your mothers. 26 00:05:06,978 --> 00:05:09,660 So in the DNA of each Mitocondria... 27 00:05:10,061 --> 00:05:13,046 the mothers of all of us are reflected. 28 00:05:14,083 --> 00:05:18,043 We have discovered who was the Eve of mythology. 29 00:05:21,290 --> 00:05:25,843 Let's go back about 200,000 years to a distant past. 30 00:05:26,473 --> 00:05:28,567 We are in Africa. 31 00:05:29,890 --> 00:05:32,443 It was here that Eve appeared. 32 00:05:33,247 --> 00:05:37,785 The first human, the first woman to carry Mitochondria. 33 00:05:38,945 --> 00:05:42,910 We call her: «Mitochondria Eve». 34 00:06:08,529 --> 00:06:11,150 Why did you stop coming here? 35 00:06:14,034 --> 00:06:16,235 I already explained it to you... 36 00:06:17,187 --> 00:06:20,495 You have to come three times each week... 37 00:06:20,496 --> 00:06:23,267 to take out everything your body does not need. 38 00:06:26,213 --> 00:06:28,606 Yes... but I'm fed up. 39 00:06:39,490 --> 00:06:40,963 In this school... 40 00:06:40,995 --> 00:06:43,248 we study the inside of our bodies... 41 00:06:43,273 --> 00:06:46,153 to understand how medicines work. 42 00:06:46,886 --> 00:06:51,671 You can wash your hands and send the germs down the drain. 43 00:06:52,076 --> 00:06:55,356 But the real fight against germs is inside you. 44 00:06:55,959 --> 00:06:59,986 There are many types of tiny things living inside of us. 45 00:07:00,058 --> 00:07:01,503 No way ... 46 00:07:01,504 --> 00:07:03,837 That's so gross! 47 00:07:04,461 --> 00:07:08,061 Yes, but I've already told you about the immune system... 48 00:07:08,101 --> 00:07:09,262 Get that out of your head. 49 00:07:09,695 --> 00:07:11,856 I don't believe it! 50 00:07:12,474 --> 00:07:19,338 You can digest food only because there are bacteria in your intestines. 51 00:07:19,363 --> 00:07:20,816 Yuck! 52 00:07:20,977 --> 00:07:23,307 Hey! A snail! 53 00:07:31,532 --> 00:07:35,032 Everyone, do you want me to tell you a cool story? 54 00:07:36,358 --> 00:07:37,678 What story? 55 00:07:39,477 --> 00:07:42,524 About the bugs inside the snail. 56 00:07:43,209 --> 00:07:44,528 Again? 57 00:07:45,361 --> 00:07:49,812 They make the shell of the snail hard. 58 00:07:49,813 --> 00:07:53,341 So, in principle, they are good for the snail. 59 00:07:53,686 --> 00:07:56,775 With a harder shell they can live longer. 60 00:07:57,481 --> 00:08:01,092 But when the snail becomes big... 61 00:08:01,440 --> 00:08:03,839 the bugs climb up to their horns. 62 00:08:04,212 --> 00:08:05,345 Why? 63 00:08:05,346 --> 00:08:06,479 Usually... 64 00:08:06,519 --> 00:08:10,669 the snails prefer dark places, but now they come out with the sun. 65 00:08:11,346 --> 00:08:13,549 The bugs make the horns swell... 66 00:08:13,975 --> 00:08:17,536 and control them so that they can wiggle. 67 00:08:17,956 --> 00:08:19,701 Why do they do that? 68 00:08:20,502 --> 00:08:25,446 Only the birds of the sky know. 69 00:08:29,286 --> 00:08:33,251 The horns look like an insect... 70 00:08:33,276 --> 00:08:35,062 that the birds love to eat. 71 00:08:37,261 --> 00:08:38,901 So... 72 00:08:38,926 --> 00:08:41,510 What the bugs really want... 73 00:08:41,911 --> 00:08:45,793 is to be able to get deep inside the stomach of the birds. 74 00:08:46,309 --> 00:08:49,495 They make the birds eat the snail. 75 00:08:49,795 --> 00:08:51,549 That's horrible!! 76 00:08:51,922 --> 00:08:54,068 We finished the science class for today! 77 00:08:54,093 --> 00:08:55,677 It's time to leave. 78 00:08:55,678 --> 00:08:57,048 Has everything been clear? 79 00:08:57,073 --> 00:08:58,799 Are we safe? 80 00:08:59,506 --> 00:09:02,610 We have lots of germs living inside of us, right? 81 00:09:04,723 --> 00:09:06,596 And will they also control us... 82 00:09:06,597 --> 00:09:08,380 when we become older? 83 00:09:10,230 --> 00:09:11,354 Do not worry. 84 00:09:11,620 --> 00:09:15,751 We are superior beings, with a more complex way of life. 85 00:09:20,124 --> 00:09:21,518 Come on! 86 00:09:43,908 --> 00:09:46,330 We have had parasites, like microbes... 87 00:09:46,331 --> 00:09:49,301 for a billion years. 88 00:09:50,996 --> 00:09:56,839 But at this moment they have become something vital for us. 89 00:09:58,261 --> 00:10:03,207 We move, we think..., all thanks to the Mitochondria. 90 00:10:06,173 --> 00:10:09,561 The two parties have decided to live together in symbiosis. 91 00:10:12,993 --> 00:10:15,340 Symbiosis - 92 00:10:15,734 --> 00:10:16,534 Teacher! 93 00:10:17,704 --> 00:10:18,504 Yes? 94 00:10:19,396 --> 00:10:25,914 For us... is there some value... 95 00:10:25,915 --> 00:10:29,115 the study of this Mitochondria? 96 00:10:33,724 --> 00:10:38,224 We already know what anomalies are in the DNA of the Mitochondria... 97 00:10:38,551 --> 00:10:43,119 They occur in cases such as Diabetes or Cirrhosis. 98 00:10:43,964 --> 00:10:48,026 So, we can say that diseases are like energy losses. 99 00:10:49,026 --> 00:10:55,436 Healthy mitochondria could grow and enter the dead cells. 100 00:10:56,290 --> 00:11:00,699 Once the cellular activity is restored, this anomaly could be corrected. 101 00:11:03,019 --> 00:11:05,119 This is what my study is based on. 102 00:11:06,593 --> 00:11:09,826 Let's see some Mitochondria! 103 00:11:23,401 --> 00:11:25,250 Thank you. 104 00:11:49,910 --> 00:11:53,263 I still can not go home, I still have work to do. 105 00:11:55,096 --> 00:11:56,696 And you can't postpone it? 106 00:11:57,211 --> 00:11:59,411 I have to deliver this data. 107 00:12:00,820 --> 00:12:04,218 We still work only with animals. 108 00:12:04,219 --> 00:12:07,728 But very soon we could be ready to help the sick. 109 00:12:13,415 --> 00:12:14,335 Oh! No! 110 00:12:17,334 --> 00:12:19,334 You forgot... 111 00:12:20,522 --> 00:12:21,722 Our... 112 00:12:22,220 --> 00:12:23,140 First... 113 00:12:24,049 --> 00:12:24,969 Anniversary. 114 00:12:26,745 --> 00:12:28,372 I bought you a gift... 115 00:12:29,372 --> 00:12:30,999 I feel stupid. 116 00:12:32,100 --> 00:12:34,874 Don't worry, I half expected it. 117 00:13:02,185 --> 00:13:03,934 I'm sorry. 118 00:13:12,895 --> 00:13:14,141 See you soon... 119 00:13:15,961 --> 00:13:17,574 Don't look at me like that! 120 00:13:19,290 --> 00:13:21,394 Work hard. 121 00:13:27,484 --> 00:13:29,184 I will leave as soon as possible! 122 00:13:44,284 --> 00:13:48,164 I've been waiting for you for so long... 123 00:13:59,131 --> 00:14:00,518 What wrong? 124 00:14:04,066 --> 00:14:05,578 Nothing. 125 00:14:47,588 --> 00:14:49,818 How was the conference, Doctor? 126 00:14:50,019 --> 00:14:51,376 Very well, I think... 127 00:14:51,977 --> 00:14:54,559 I have tried with this concentrate. 128 00:14:54,960 --> 00:14:55,726 And what have you learned? 129 00:14:55,726 --> 00:14:56,821 It is a tinted gel. 130 00:14:57,234 --> 00:14:58,034 I agree. 131 00:14:58,920 --> 00:15:02,611 Dr. Nagashima! The rat livers are improving! 132 00:15:20,258 --> 00:15:23,098 The healthy cells that we introduced last week... 133 00:15:23,098 --> 00:15:24,839 they have reversed atrophy. 134 00:15:26,970 --> 00:15:28,570 These are from the last week. 135 00:15:32,687 --> 00:15:34,358 At last! 136 00:15:36,006 --> 00:15:38,750 Cultivate these cells and monitor the mitochondria. 137 00:15:51,414 --> 00:15:52,310 Nagashima! 138 00:15:52,584 --> 00:15:55,049 Do not make Miss Asakura work too hard. 139 00:15:55,450 --> 00:15:58,503 She has to submit a project next month. 140 00:15:58,861 --> 00:16:00,207 All right, sir. 141 00:16:00,408 --> 00:16:01,971 There's no problem 142 00:16:01,972 --> 00:16:05,195 I learn a lot by helping Prof. Nagashima. 143 00:16:06,094 --> 00:16:09,450 I understand why you are so excited about mitochondria. 144 00:16:10,650 --> 00:16:13,873 There must be so much to discover... 145 00:16:15,714 --> 00:16:18,333 - Excuse us. - With your permission... 146 00:16:41,215 --> 00:16:43,800 The Mitochondria have every time... 147 00:16:43,801 --> 00:16:48,195 a different way of life, right? Like bacteria. 148 00:16:49,135 --> 00:16:49,948 Yeah, so what? 149 00:16:51,349 --> 00:16:53,942 The children were asking me... 150 00:16:54,342 --> 00:16:59,774 if one day they could take control of a human body. 151 00:17:00,965 --> 00:17:04,003 There is a theory that says... 152 00:17:06,780 --> 00:17:12,211 Mitochondria do not have enough DNA to live by themselves. 153 00:17:13,320 --> 00:17:18,764 But some can be transferred outside the nucleus. 154 00:17:19,671 --> 00:17:24,165 Which means that some of the core genes... 155 00:17:24,758 --> 00:17:27,630 ... are associated with the Mitocondria. 156 00:17:28,446 --> 00:17:30,707 Very good, but... 157 00:17:31,128 --> 00:17:34,992 Have you become worried about the mitochondria? 158 00:18:07,000 --> 00:18:08,600 «CULTIVATION OF LIVER CELLS». 159 00:19:10,521 --> 00:19:12,121 Dr. Nagashima! 160 00:19:59,027 --> 00:20:01,827 Are you a relative of Kiyomi Nagashima? 161 00:20:04,959 --> 00:20:05,880 How is she...? 162 00:20:11,610 --> 00:20:12,782 Very badly injured. 163 00:20:16,278 --> 00:20:17,677 Will she recover from this? 164 00:20:18,945 --> 00:20:22,318 She is suffering respiratory arrest due to a stroke. 165 00:20:23,031 --> 00:20:25,104 They are operating now. 166 00:20:29,705 --> 00:20:32,526 Please... Notify the rest of the family. 167 00:21:17,920 --> 00:21:19,117 You are her husband, right? 168 00:21:20,716 --> 00:21:21,974 Yes. 169 00:21:29,470 --> 00:21:34,165 There was a massive cerebral hemorrhage. 170 00:21:35,566 --> 00:21:38,365 We operated on her as soon as she arrived. 171 00:21:38,426 --> 00:21:40,926 We have put her on assisted breathing. 172 00:21:41,166 --> 00:21:44,146 She can not breathe on her own. 173 00:21:46,346 --> 00:21:50,407 We have run tests with high doses of stimulants. 174 00:21:50,408 --> 00:21:52,754 There is loss of brain activity... 175 00:21:53,355 --> 00:21:55,555 and damage to her spine. 176 00:22:00,529 --> 00:22:03,329 What are the chances of her coming out of the coma? 177 00:22:08,986 --> 00:22:11,423 Sorry to tell you this... 178 00:22:11,824 --> 00:22:15,022 but she is on the verge of brain death. 179 00:22:29,179 --> 00:22:30,779 It's me... 180 00:22:32,132 --> 00:22:34,332 Can you hear me? 181 00:22:38,694 --> 00:22:40,565 Kiyomi. 182 00:22:44,766 --> 00:22:46,746 You have to wake up! 183 00:22:48,940 --> 00:22:51,461 Today is a great day... 184 00:22:53,810 --> 00:22:55,810 Our first... 185 00:23:59,725 --> 00:24:01,070 Toshiaki! 186 00:24:14,740 --> 00:24:16,340 Kiyomi... 187 00:24:17,590 --> 00:24:20,790 It's still early for you to leave us, like your mother... 188 00:24:30,799 --> 00:24:33,718 This is the brain activity tonight. 189 00:24:35,518 --> 00:24:39,677 This is six hours later. 190 00:24:40,678 --> 00:24:43,236 All the tests are negative. 191 00:24:43,637 --> 00:24:46,116 Her brain has stopped working. 192 00:24:48,216 --> 00:24:51,173 It's definitive... she's clinically dead. 193 00:25:30,715 --> 00:25:31,910 Mr. Nagashima. 194 00:25:33,110 --> 00:25:36,088 This is Miss Odagiri, coordinator of transplants. 195 00:25:36,489 --> 00:25:37,689 How are you? 196 00:25:40,394 --> 00:25:45,034 Kyomi registered her kidneys as organs for transplant. 197 00:25:46,744 --> 00:25:48,344 Transplants? 198 00:25:50,804 --> 00:25:55,083 Kyomi was registered in the donor bank. 199 00:25:56,284 --> 00:25:57,884 Did you know? 200 00:26:00,474 --> 00:26:04,763 She registered about six months ago... almost without thinking. 201 00:26:05,564 --> 00:26:11,293 Her kidney can save a patient with chronic kidney failure. 202 00:26:12,694 --> 00:26:14,098 Unfortunately... 203 00:26:14,699 --> 00:26:17,458 There is no kind of cure for that state. 204 00:26:17,858 --> 00:26:21,269 The patient must undergo dialysis on a regular basis. 205 00:26:24,386 --> 00:26:27,805 I assure you that your wife's kidney will go to a good cause. 206 00:26:28,406 --> 00:26:31,206 I think we should respect her will... 207 00:26:32,574 --> 00:26:36,610 if that's what she wanted... 208 00:26:40,010 --> 00:26:42,810 Are you her father? 209 00:26:44,548 --> 00:26:47,348 Could you sign for family consent in this document? 210 00:26:52,826 --> 00:26:54,194 Could we, at least... 211 00:26:54,595 --> 00:26:56,195 study if there is any incompatibility? 212 00:28:50,313 --> 00:28:53,513 We have a possible kidney donor in the city. 213 00:28:55,422 --> 00:28:58,161 A 25-year-old woman, brain dead from hemorrhage. 214 00:28:59,964 --> 00:29:02,089 I compared the results of your HLA... 215 00:29:03,090 --> 00:29:04,610 looking for a compatible receiver. 216 00:29:07,578 --> 00:29:11,438 Your patient tops the list. 217 00:29:14,193 --> 00:29:15,714 I understand. 218 00:29:17,327 --> 00:29:20,127 There is no other possible receiver. 219 00:29:24,567 --> 00:29:26,466 Can I make the request? 220 00:29:28,066 --> 00:29:29,238 Sure, please... 221 00:29:29,438 --> 00:29:30,630 I need some time. 222 00:29:31,031 --> 00:29:36,054 The family has not yet agreed. 223 00:29:38,910 --> 00:29:41,542 Which hospital is it? 224 00:30:05,683 --> 00:30:07,316 Nurse... 225 00:30:09,631 --> 00:30:14,291 Does this mean that Kiyomi is dead? 226 00:30:34,675 --> 00:30:38,306 I come to beg you to allow the transplant. 227 00:30:39,107 --> 00:30:43,038 His wife's compatibility tests have found a receiver. 228 00:30:44,038 --> 00:30:45,238 Mr. Nagashima. 229 00:30:46,359 --> 00:30:49,166 Mr. Nagashima, I understand how you feel... 230 00:30:49,166 --> 00:30:51,733 but this was her last will. 231 00:30:52,734 --> 00:30:54,274 The kidney is not going to be wasted. 232 00:30:55,674 --> 00:31:01,897 Please, free the patient from her suffering. 233 00:31:02,298 --> 00:31:04,834 She is a 12 year old girl. 234 00:31:08,547 --> 00:31:11,060 Yoshizumi, from the Central Hospital. 235 00:31:12,861 --> 00:31:15,096 Doctor, I'll take care of this. 236 00:31:15,197 --> 00:31:17,405 Please, let us use that kidney. 237 00:31:17,806 --> 00:31:19,666 Please Doctor... This goes against the rules! 238 00:31:20,067 --> 00:31:21,593 She's just a little girl! 239 00:31:22,194 --> 00:31:24,490 I want to cure her and let her live! Mr. Nagashima! 240 00:31:25,239 --> 00:31:26,039 Mr. Nagashima! 241 00:31:26,827 --> 00:31:27,627 Doctor! 242 00:31:30,054 --> 00:31:32,502 Just listen to me! Please! 243 00:31:34,299 --> 00:31:35,099 Mr. Nagashima! 244 00:31:41,182 --> 00:31:44,022 Give it to me! I beg you! 245 00:31:48,669 --> 00:31:51,770 I've already disappointed that girl before. 246 00:31:58,129 --> 00:32:02,369 Two years ago, I did another kidney transplant. 247 00:32:04,248 --> 00:32:05,918 I thought everything had gone well... 248 00:32:08,493 --> 00:32:11,169 but in the end her body rejected it. 249 00:32:12,194 --> 00:32:15,394 The girl trusted me... 250 00:32:18,293 --> 00:32:19,500 and I failed. 251 00:32:25,661 --> 00:32:27,517 Please! 252 00:32:27,918 --> 00:32:30,138 Give me another chance! 253 00:32:31,460 --> 00:32:33,480 Kiyomi is alive. 254 00:32:41,158 --> 00:32:45,338 Kiyomi... she is not dead. 255 00:32:49,297 --> 00:32:50,417 She is still alive! 256 00:36:23,562 --> 00:36:25,601 Ok, I accept. 257 00:36:28,102 --> 00:36:29,349 Really? 258 00:36:30,866 --> 00:36:33,125 But with one condition... 259 00:36:35,626 --> 00:36:41,014 I will give you the kidney if in exchange you give me the liver. 260 00:36:45,297 --> 00:36:46,617 For what? 261 00:36:47,995 --> 00:36:50,103 I'm not a doctor... 262 00:36:50,370 --> 00:36:52,221 so I can't do the operation myself. 263 00:36:54,786 --> 00:36:58,226 So, you will extract it and give it to me. 264 00:37:01,984 --> 00:37:02,784 But... 265 00:37:04,506 --> 00:37:07,173 What do you intend to do with it? 266 00:37:29,904 --> 00:37:30,930 Mariko... 267 00:37:35,073 --> 00:37:36,297 Mariko... 268 00:37:40,841 --> 00:37:45,502 Can you trust me one more time? 269 00:38:14,662 --> 00:38:17,203 Her heart has stopped. 270 00:38:22,698 --> 00:38:25,019 11:31 a. m. 271 00:38:26,020 --> 00:38:28,107 Time of death confirmed. 272 00:38:28,474 --> 00:38:30,674 I could not do anything to save her. 273 00:38:44,875 --> 00:38:46,557 We will start the operation now. 274 00:38:46,558 --> 00:38:48,517 I beg you... 275 00:38:50,565 --> 00:38:52,560 Please, Doctor... 276 00:38:56,002 --> 00:38:57,284 What's going on here? 277 00:38:57,326 --> 00:38:58,526 Hurry up. 278 00:39:25,115 --> 00:39:27,220 33 minutes after death. 279 00:39:30,261 --> 00:39:32,261 12:04 p.m. 280 00:39:34,718 --> 00:39:36,599 Let's start the extraction. 281 00:40:01,600 --> 00:40:04,400 Merry Christmas! 282 00:40:10,606 --> 00:40:12,746 Take it ... next. 283 00:40:15,218 --> 00:40:17,524 Give me two, please. 284 00:40:25,626 --> 00:40:27,325 Here you go... 285 00:40:27,992 --> 00:40:29,412 Two. 286 00:40:31,145 --> 00:40:34,406 Today is my birthday... so give me two. 287 00:40:38,372 --> 00:40:40,662 Really? 288 00:40:50,636 --> 00:40:53,689 Kataoka... Kiyomi? 289 00:40:55,686 --> 00:40:58,459 It is the same symbol as to write «Christmas Eve». 290 00:41:02,591 --> 00:41:04,045 Happy Birthday. 291 00:41:06,847 --> 00:41:08,085 Only one? 292 00:41:10,387 --> 00:41:13,193 Give me a break! 293 00:41:26,913 --> 00:41:28,093 What is it? 294 00:41:31,161 --> 00:41:35,022 The students in the lab are nagging me. 295 00:41:35,945 --> 00:41:37,710 They say... 296 00:41:38,111 --> 00:41:39,991 I should do something to not let you escape. 297 00:41:42,154 --> 00:41:43,360 Is that right... 298 00:41:46,963 --> 00:41:48,563 Perhaps I might escape. 299 00:41:59,902 --> 00:42:00,702 "I ..." 300 00:42:03,135 --> 00:42:07,801 was waiting so long for you ... 301 00:42:13,569 --> 00:42:16,025 I, too... 302 00:42:16,547 --> 00:42:18,698 Since the first time... 303 00:42:18,798 --> 00:42:21,213 that I saw you... 304 00:42:21,253 --> 00:42:22,244 waited so long. 305 00:42:55,749 --> 00:42:56,949 Let's get them out. 306 00:43:22,222 --> 00:43:23,726 Something happened? 307 00:43:23,986 --> 00:43:25,127 Nothing... 308 00:43:27,662 --> 00:43:28,927 It's hot... 309 00:43:47,506 --> 00:43:50,516 Your daughter will be fine. 310 00:43:51,517 --> 00:43:53,578 We will prepare everything. 311 00:43:53,579 --> 00:43:55,659 The doctor will arrive right away. 312 00:44:36,845 --> 00:44:39,458 Doctor... what are you doing? 313 00:44:39,927 --> 00:44:41,178 Doctor! 314 00:44:43,923 --> 00:44:45,212 What's going on? 315 00:44:45,813 --> 00:44:47,082 Extracting the liver. 316 00:44:47,346 --> 00:44:49,486 We are not here for that! 317 00:44:49,973 --> 00:44:51,306 No time to lose! 318 00:44:51,558 --> 00:44:52,993 Quiet! 319 00:45:05,306 --> 00:45:06,593 Wait here. 320 00:45:10,992 --> 00:45:12,166 Here is your wife's liver. 321 00:45:18,026 --> 00:45:18,886 Mr. Nagashima! 322 00:45:23,042 --> 00:45:25,842 And what about the body of your wife? 323 00:46:07,397 --> 00:46:08,690 Is everything alright? 324 00:46:14,565 --> 00:46:16,485 Would you mind leaving me? 325 00:46:28,302 --> 00:46:29,488 Get out of here! 326 00:46:32,266 --> 00:46:35,192 Shouldn't you be with your wife? 327 00:46:39,562 --> 00:46:41,928 Kiyomi... is here. 328 00:47:19,007 --> 00:47:21,407 Time since the donor's death: 123 minutes. 329 00:47:23,595 --> 00:47:25,849 69 minutes from extraction. 330 00:47:27,779 --> 00:47:31,280 I am undertaking the transplant. 331 00:47:32,081 --> 00:47:35,010 Time: 1:34 p.m. 332 00:47:37,030 --> 00:47:37,867 The kidney... 333 00:49:35,287 --> 00:49:35,847 Mariko... 334 00:49:35,914 --> 00:49:39,074 We are taking her to a sterile room. Do not worry. 335 00:49:43,791 --> 00:49:45,251 Everything went well. 336 00:49:45,691 --> 00:49:46,570 Doctor! 337 00:49:46,937 --> 00:49:49,957 This time... everything has gone great. 338 00:49:56,610 --> 00:49:58,283 Thank you. 339 00:51:13,281 --> 00:51:16,341 Kiyomi... Kiyomi... 340 00:51:41,964 --> 00:51:45,983 We had not seen her so happy for many years. 341 00:51:50,623 --> 00:51:52,676 They don't know how much I appreciate it... 342 00:51:53,350 --> 00:51:55,429 ... the people who donated it. 343 00:56:10,155 --> 00:56:12,002 Doctor! It's Mariko ...! 344 00:56:18,244 --> 00:56:19,924 Mariko... what's the matter with you? 345 00:56:20,057 --> 00:56:21,137 It was just a dream. 346 00:56:21,246 --> 00:56:22,379 It was not a dream! 347 00:56:22,492 --> 00:56:23,838 It was just a nightmare, Mariko! 348 00:56:23,863 --> 00:56:25,558 It was not a dream! 349 00:56:25,585 --> 00:56:27,532 Everything will be fine... the Doctor is already here. 350 00:56:28,092 --> 00:56:30,619 Calm down, Mariko... 351 00:56:31,746 --> 00:56:32,806 Underneath! 352 00:56:33,506 --> 00:56:35,106 It's calling out! 353 00:56:36,326 --> 00:56:37,755 It's in my stomach! 354 00:56:38,002 --> 00:56:39,651 Doctor, quickly take it out! 355 00:56:39,676 --> 00:56:41,423 Quick! Take it out! 356 00:56:41,638 --> 00:56:43,005 Quickly, take it out! 357 00:56:43,317 --> 00:56:44,950 Mariko, Mariko! 358 00:56:45,278 --> 00:56:46,851 The operation was a success! 359 00:56:47,051 --> 00:56:49,778 There is nothing to worry about. 360 00:56:57,081 --> 00:56:59,176 Be brave, Mariko... 361 00:56:59,894 --> 00:57:02,087 You're fine... You're fine, Mariko... 362 00:58:20,819 --> 00:58:22,410 That's right, Kiyomi... 363 00:58:24,610 --> 00:58:25,813 Come on... 364 00:58:40,611 --> 00:58:42,628 These are cells of the new kidney... 365 00:58:42,828 --> 00:58:45,854 expanded 16,000 times. 366 00:58:49,391 --> 00:58:50,991 What do you think about this? 367 00:58:51,750 --> 00:58:53,910 I've never seen a Mitochondria like this. 368 00:59:01,795 --> 00:59:03,881 The mitochondria ... 369 00:59:07,028 --> 00:59:08,695 they are three times bigger... 370 00:59:10,910 --> 00:59:12,729 ... compared to their usual size. 371 00:59:13,560 --> 00:59:15,620 Also... there is a greater amount. 372 00:59:15,834 --> 00:59:20,427 And they are reproducing much faster every day. 373 00:59:20,827 --> 00:59:23,682 We took this after the operation... 374 00:59:24,082 --> 00:59:25,682 and it seemed very strange. 375 00:59:29,418 --> 00:59:33,411 You gave the donor's liver to her husband, right? 376 00:59:35,126 --> 00:59:36,566 What about it? 377 00:59:40,766 --> 00:59:43,705 What is this, Kiyomi? 378 01:00:48,401 --> 01:00:49,432 Kiyomi... 379 01:00:54,046 --> 01:00:55,052 Kiyomi? 380 01:01:03,379 --> 01:01:06,378 Can we talk about my project? 381 01:01:06,779 --> 01:01:07,820 I am very busy. 382 01:02:08,711 --> 01:02:11,157 Is there something about your wife...? 383 01:02:12,564 --> 01:02:14,486 What do you think I know? 384 01:02:17,534 --> 01:02:19,850 The cells of the kidney are growing like crazy! 385 01:02:22,804 --> 01:02:23,790 Mr. Nagashima. 386 01:02:25,620 --> 01:02:27,966 Nagashima, what happened to the liver? 387 01:02:29,366 --> 01:02:31,074 What did you do with it? 388 01:02:33,326 --> 01:02:34,773 Kiyomi is alive. 389 01:02:37,099 --> 01:02:37,939 Do you think... 390 01:02:39,199 --> 01:02:42,197 What was going to stop me while she was dying? 391 01:02:50,546 --> 01:02:52,338 You will not be growing those cells, right? 392 01:02:54,326 --> 01:02:59,107 No one else would have had to watch her die. 393 01:03:00,960 --> 01:03:02,180 But... 394 01:03:04,600 --> 01:03:06,806 I've found a way to keep Kiyomi alive. 395 01:03:08,045 --> 01:03:09,446 But what's wrong with you? 396 01:03:09,686 --> 01:03:13,218 Why are you cultivating your own wife's cells? 397 01:03:14,267 --> 01:03:16,193 Each and every one of those cells... 398 01:03:17,547 --> 01:03:18,827 ... it's Kiyomi. 399 01:03:26,077 --> 01:03:27,470 Are you crazy! 400 01:03:34,201 --> 01:03:38,354 You kept Kiyomi alive until you transplanted the kidney... 401 01:03:38,841 --> 01:03:40,250 to your patient. 402 01:03:41,550 --> 01:03:45,848 And I made her live again by growing her cells. 403 01:03:48,068 --> 01:03:50,115 What is the difference? 404 01:04:21,791 --> 01:04:26,796 «The stimulation of peroxybial enzymes springs... 405 01:04:27,016 --> 01:04:29,962 from unsaturated fatty acids of the Mitochondria... 406 01:04:30,608 --> 01:04:32,694 from the livers of rats ». 407 01:04:55,659 --> 01:04:59,704 «The stimulation of peroxybial enzymes springs... 408 01:05:02,193 --> 01:05:08,834 «The stimulation of peroxybial enzymes springs... from unsaturated fatty acids... 409 01:05:09,590 --> 01:05:11,930 «... from the fatty acids of the Mitochondria... » 410 01:05:14,590 --> 01:05:16,337 «... the fatty acids of the Mitochondria... » 411 01:05:17,470 --> 01:05:19,730 «... from the fatty acids of the Mitochondria... » 412 01:05:38,211 --> 01:05:42,124 «The stimulation of peroxybial enzymes ... » 413 01:14:37,687 --> 01:14:39,887 To ... shi ... a ... ki 414 01:14:44,802 --> 01:14:45,804 Kiyomi? 415 01:14:52,485 --> 01:14:54,197 Look at my body. 416 01:15:00,370 --> 01:15:01,969 You remember... 417 01:15:04,370 --> 01:15:05,968 ... this body? 418 01:15:08,362 --> 01:15:11,044 You had it near you so many times... 419 01:15:26,671 --> 01:15:29,964 You loved only me. 420 01:15:38,476 --> 01:15:40,077 It's me... Kiyomi. 421 01:15:53,995 --> 01:15:55,197 Toshiaki. 422 01:20:27,758 --> 01:20:29,558 It's raining. 423 01:20:29,559 --> 01:20:31,957 I can hear it saying Toshiaki again. 424 01:20:33,158 --> 01:20:35,496 I could hear it the first time that I saw Toshiaki. 425 01:20:36,003 --> 01:20:37,502 That mysterious voice. 426 01:20:38,516 --> 01:20:40,242 Like a ringing in my ears. 427 01:20:42,347 --> 01:20:44,666 I felt a strange heat feeling its way over my body... 428 01:20:44,853 --> 01:20:46,853 ...reaching out from inside. 429 01:20:48,112 --> 01:20:50,845 My body feels hot, like my blood is going to burst... 430 01:20:51,301 --> 01:20:52,547 and I can not breathe. 431 01:20:54,234 --> 01:20:56,974 When Toshiaki talks to me about his work... 432 01:20:57,387 --> 01:20:59,894 The voice inside of me seems to be pleased. 433 01:21:01,476 --> 01:21:05,902 The word "Mitochondria" alone makes my heart throb violently... 434 01:21:06,869 --> 01:21:07,809 and fills it with joy... 435 01:21:08,169 --> 01:21:09,615 It's raging inside me. 436 01:21:10,762 --> 01:21:12,049 I can't really understand it... 437 01:21:12,909 --> 01:21:13,941 As it stands ... 438 01:21:15,362 --> 01:21:17,408 I am ruled by that voice... 439 01:21:18,420 --> 01:21:21,006 by that proud voice... 440 01:21:31,222 --> 01:21:33,888 The only one you loved... It was me. 441 01:21:36,034 --> 01:21:39,567 Kiyomi loved you... 442 01:21:40,742 --> 01:21:42,742 because I made her. 443 01:21:44,313 --> 01:21:49,607 I had her talk to you that Christmas... 444 01:21:51,834 --> 01:21:53,561 with a voice that would make you fall in love. 445 01:21:55,541 --> 01:21:57,540 Your breathing accelerated. 446 01:21:59,741 --> 01:22:01,740 I had chosen you... 447 01:22:04,253 --> 01:22:05,376 You would be... 448 01:22:07,418 --> 01:22:09,820 ... the one who could cultivate us. 449 01:22:13,001 --> 01:22:14,015 You... 450 01:22:15,935 --> 01:22:16,935 Who are you? 451 01:22:18,736 --> 01:22:24,448 I had been waiting for you... 452 01:22:34,645 --> 01:22:36,266 I'm scared... I'm scared... I'm scared... I'm scared... 453 01:24:07,452 --> 01:24:08,816 Doctor? 454 01:24:11,606 --> 01:24:14,888 I'm about to give my conference paper. 455 01:24:16,750 --> 01:24:20,349 I want to relay something very important... 456 01:24:21,379 --> 01:24:24,254 ...for the good of humanity. 457 01:24:34,682 --> 01:24:36,615 « We believe curative treatment will be possible... » 458 01:24:37,532 --> 01:24:42,065 « ... by replacing abnormal genes with healthy mitochondrian genes. » 459 01:24:42,599 --> 01:24:49,984 « Mitochondria are cytoplasmic organelles of all eukaryotic cells... » 460 01:24:50,484 --> 01:24:54,357 « ... engaging in aerobic respiration. » 461 01:24:54,740 --> 01:24:59,533 « And also, the source of most Asp in those cells. » 462 01:25:00,832 --> 01:25:09,718 « However, your suggestion of it having curative effects to heal diseases ... » 463 01:25:09,743 --> 01:25:14,125 « ... is still only a hypothesis, and has not been proven. » 464 01:25:16,643 --> 01:25:19,477 « Injecting cells with healthy mitochondrian ... » 465 01:25:19,498 --> 01:25:22,893 « ... has shown production of a new source of energy in the ailing cells. » 466 01:25:23,220 --> 01:25:27,492 « The result is a so-called rejuvenation of the cells. Furthermore ... » 467 01:25:27,517 --> 01:25:29,700 I was looking for you. 468 01:25:30,976 --> 01:25:33,683 The condition of the girl is more unusual every day. 469 01:25:33,913 --> 01:25:35,683 Her uterus is changing. 470 01:25:36,450 --> 01:25:38,290 And it's also changing its cellular structure. 471 01:25:40,163 --> 01:25:41,716 Thank you very much - 472 01:25:42,408 --> 01:25:47,006 Next, Sachiko Asakura, from the National University of Biochemistry... 473 01:25:47,983 --> 01:25:50,382 The subject is «Retinoid Receptors... 474 01:25:50,383 --> 01:25:52,782 in the DNA Derivatives of the Mitochondria ». 475 01:26:33,729 --> 01:26:34,729 Today ... 476 01:26:35,635 --> 01:26:38,882 ... you are fortunate to be the human beings who are going to hear me speak. 477 01:26:40,422 --> 01:26:46,115 You will be the first to hear about the new world that will begin. 478 01:26:48,767 --> 01:26:56,594 And I am also happy to be able to address human beings. 479 01:26:58,462 --> 01:26:59,863 At last ... 480 01:27:01,269 --> 01:27:04,466 the Mitochondria are going to be free. 481 01:27:09,552 --> 01:27:12,339 What's wrong with that girl? 482 01:27:14,752 --> 01:27:18,239 The Mitochondria is talking to us. 483 01:27:18,372 --> 01:27:24,472 We have watched you since you were microorganisms. 484 01:27:27,094 --> 01:27:30,978 We gave you the energy with which you have evolved. 485 01:27:33,702 --> 01:27:40,981 We even remember your ancestor... Eve. The Mitochondria had already taken over. 486 01:27:46,557 --> 01:27:50,464 We have waited a long time... 487 01:27:51,637 --> 01:27:52,930 until this moment. 488 01:27:55,161 --> 01:27:56,847 For a billion years ... 489 01:27:58,561 --> 01:28:01,687 You... you're Eve, right? 490 01:28:03,901 --> 01:28:04,754 You ... 491 01:28:04,779 --> 01:28:05,561 ... damn you! 492 01:28:05,995 --> 01:28:07,135 This is not your thesis ... 493 01:28:30,647 --> 01:28:32,598 Be silent! 494 01:28:35,013 --> 01:28:40,684 We have power over the Mitochondria of your cells... 495 01:28:42,005 --> 01:28:44,792 and we can control the energy that they transmit. 496 01:28:45,410 --> 01:28:49,851 Mitochondrial energy converted into heat impulses ... 497 01:28:50,697 --> 01:28:52,131 Thousands of volts! 498 01:28:54,690 --> 01:28:58,851 But, it can't be true...! It's crazy! 499 01:29:00,285 --> 01:29:05,738 We had to wait for humanity to evolve to this point. 500 01:29:08,394 --> 01:29:12,756 You have done better than we thought... 501 01:29:14,642 --> 01:29:17,496 but your mission is over. 502 01:29:18,509 --> 01:29:19,569 Now... 503 01:29:21,049 --> 01:29:24,682 We are going to take your place. 504 01:29:26,022 --> 01:29:29,229 A new evolution will begin. 505 01:29:31,778 --> 01:29:37,445 The transfer of a flawless sperm has already begun. 506 01:29:39,489 --> 01:29:44,323 Our descendants will be... the definitive way of life. 507 01:29:49,656 --> 01:29:51,190 Unfortunately... 508 01:29:52,790 --> 01:29:56,088 you will not be here to see it blossom. 509 01:29:57,409 --> 01:30:01,330 We... we will destroy all of you. 510 01:30:36,627 --> 01:30:37,747 Asakura! 511 01:30:39,861 --> 01:30:40,741 She is okay... 512 01:30:45,431 --> 01:30:46,851 What have we done... 513 01:30:49,383 --> 01:30:50,871 ... me, and the mitochondria? 514 01:30:55,420 --> 01:30:57,947 The mitochondria and I are going to have a child. 515 01:31:06,264 --> 01:31:08,370 The sperm would have already been transferred, right? 516 01:31:08,910 --> 01:31:12,057 So why can't the mitochondria produce a child using the sperm by itself? 517 01:31:21,509 --> 01:31:23,108 My patient... 518 01:31:27,138 --> 01:31:28,698 ... her uterus is transforming. 519 01:31:37,362 --> 01:31:38,590 Get out!!! 520 01:31:39,190 --> 01:31:40,456 - Any problem? - No! 521 01:31:40,596 --> 01:31:41,543 Mariko, what is the matter? 522 01:31:41,730 --> 01:31:42,707 Get away!! 523 01:31:43,332 --> 01:31:44,770 - Mariko! - Get away!! 524 01:31:44,797 --> 01:31:45,879 - What's wrong? - Get away ... 525 01:31:46,550 --> 01:31:47,656 Mariko, what's the matter with you? 526 01:31:48,044 --> 01:31:49,044 Mariko. 527 01:31:49,537 --> 01:31:50,531 So hot. 528 01:31:58,248 --> 01:31:59,860 - Where? - I'm too hot! 529 01:32:04,008 --> 01:32:05,021 So hot ... 530 01:32:11,928 --> 01:32:13,574 What has happened? 531 01:32:14,703 --> 01:32:18,434 Kiyomi's mitochondria can not reproduce on their own. 532 01:32:18,937 --> 01:32:21,825 They need a womb. 533 01:32:22,826 --> 01:32:25,298 They controlled Kiyomi to have her kidney donated. 534 01:32:26,313 --> 01:32:28,154 They had everything planned from the start! 535 01:32:28,967 --> 01:32:30,535 Even that I would cultivate her cells. 536 01:32:30,988 --> 01:32:32,415 And what about my patient? 537 01:32:43,634 --> 01:32:44,682 Mariko! 538 01:33:27,298 --> 01:33:27,928 This way! 539 01:33:58,076 --> 01:33:58,822 Mariko! 540 01:34:15,336 --> 01:34:16,336 It's here... 541 01:34:21,272 --> 01:34:22,402 It's here? 542 01:34:23,868 --> 01:34:24,948 What's here? 543 01:35:48,679 --> 01:35:49,946 Who the hell are you? 544 01:35:57,217 --> 01:35:58,364 Stop this, Kiyomi! 545 01:36:05,406 --> 01:36:07,565 Give me my daughter...! 546 01:38:35,631 --> 01:38:36,210 Hold it! 547 01:38:54,464 --> 01:38:55,744 Do not let it leave the building! 548 01:41:25,823 --> 01:41:26,817 Doctor! 549 01:41:49,977 --> 01:41:52,337 Doctor... help me... 550 01:41:54,933 --> 01:41:57,780 I'm here... Doctor... 551 01:41:58,477 --> 01:41:59,906 Mariko? 552 01:42:02,046 --> 01:42:03,986 Doctor... 553 01:42:07,411 --> 01:42:10,051 Doctor, I'm here... 554 01:42:14,155 --> 01:42:15,988 Doctor... 555 01:42:19,355 --> 01:42:22,374 Doctor, help me... 556 01:42:32,812 --> 01:42:37,633 Doctor... I'm here. 557 01:43:21,730 --> 01:43:22,969 Are you okay? 558 01:43:42,305 --> 01:43:43,557 The rooftop... 559 01:43:47,923 --> 01:43:49,438 Doctor! 560 01:44:27,929 --> 01:44:29,105 Wait! 561 01:44:36,150 --> 01:44:37,943 Let the girl leave! 562 01:44:45,420 --> 01:44:47,026 Let her go! 563 01:44:49,809 --> 01:44:51,999 Let that girl go, Kiyomi! 564 01:44:54,398 --> 01:44:55,997 Do not meddle. 565 01:44:59,397 --> 01:45:00,995 This is evolution. 566 01:45:04,150 --> 01:45:09,117 The child that she is going to give birth to will be the pure "Mitochondria Eve". 567 01:45:12,266 --> 01:45:13,379 Kiyomi? 568 01:45:17,166 --> 01:45:18,644 Are you there? 569 01:45:24,930 --> 01:45:27,030 We grew in strength... 570 01:45:29,782 --> 01:45:32,395 ... so, we took control while she was driving. 571 01:45:32,776 --> 01:45:35,469 We shut down her nervous system. We caused the accident. 572 01:45:39,837 --> 01:45:47,489 And as we expected... you cultivated her cells. 573 01:45:49,643 --> 01:45:52,443 And we came into possession of the perfect formula. 574 01:46:02,863 --> 01:46:05,743 Say goodbye... to humanity. 575 01:46:32,828 --> 01:46:34,818 I can not forget you. 576 01:46:36,218 --> 01:46:38,040 Neither do we. 577 01:46:39,463 --> 01:46:41,457 Since I had to fall in love with you... 578 01:46:41,563 --> 01:46:43,605 ...it was difficult to train Kiyomi. 579 01:46:48,652 --> 01:46:51,306 The first time I saw her... 580 01:46:51,942 --> 01:46:53,612 «Christmas Eve». 581 01:46:55,957 --> 01:47:01,664 The night you and Kiyomi met... we changed fate. 582 01:47:11,677 --> 01:47:15,017 We created the Kiyomi that you loved. 583 01:47:20,955 --> 01:47:25,642 But ... I saw her before that. 584 01:47:32,375 --> 01:47:36,329 Kiyomi's first day of college... 585 01:47:36,330 --> 01:47:37,729 on the Campus. 586 01:47:43,979 --> 01:47:47,310 She was wearing a pink dress... 587 01:47:52,705 --> 01:47:57,245 and a bright and innocent smile... 588 01:48:02,541 --> 01:48:04,300 I stared at her... 589 01:48:07,706 --> 01:48:09,706 thinking how wonderful it would be... 590 01:48:12,703 --> 01:48:14,216 to be with her. 591 01:48:37,728 --> 01:48:43,583 We made Kiyomi's heart beat hard for you. 592 01:48:45,876 --> 01:48:48,636 We created her love for you. 593 01:48:52,708 --> 01:48:54,161 Kiyomi... 594 01:49:26,755 --> 01:49:28,009 Do not come near. 595 01:49:32,604 --> 01:49:34,641 - Come to me. - STOP! 596 01:49:44,119 --> 01:49:45,385 Come... 597 01:49:47,046 --> 01:49:48,379 Come back with me... 598 01:50:00,751 --> 01:50:02,171 Come back with me! 599 01:50:02,864 --> 01:50:03,724 Stop! 600 01:50:06,445 --> 01:50:07,733 Get away! 601 01:50:30,747 --> 01:50:34,355 Let me hold you. 602 01:53:54,877 --> 01:53:56,537 What happened? 603 01:54:09,787 --> 01:54:11,440 You had a bad dream